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001-es BibID:BIBFORM033789
Első szerző:Zeher Margit (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Cím:Macrophages containing factor XIII subunit a in salivary glands of patients with Sjögrens's syndrome / Zeher M., Ádány R., Nagy G., Gomez R., Szegedi Gy.
Dátum:1991
Megjegyzések:Minor labial salivary glands obtained at biopsy from patients with Sjögren's syndrome were investigated by immunomorphological methods for the presence of monocyte-derived macrophages. According to our observations published earlier the immunomorphological detection of factor XIII subunit a is a useful marker for recognizing cells of monocyte/macrophage lineage. Factor XIII subunit a was detected by a highly sensitive immunoperoxidase staining, and cells containing this coagulation enzyme were characterized by double immunofluorescence stainings. Factor XIII subunit a+ cells were found to be highly accumulated at the interface of normal tissue and peritubular infiltrate. In double immunofluorescence labelling systems factor XIII subunit a+ cells were simultaneously labelled by RFD7 and Dako-antimacrophage monoclonal antibodies. They also expressed HLA-DR antigen as revealed by a reaction with RFDR2 monoclonal antibody. The results suggest that monocyte-derived tissue macrophages are present in salivary glands of patients with Sjögren's syndrome and have a characteristic distribution. It can be assumed that they have a role in the demarcation of peritubular inflammation and thus have an effect on the progression of the disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Investigational Allergology and Clinical Immunology. - 1 : 4 (1991), p. 261-265. -
További szerzők:Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Nagy Gábor (fogorvos) Gomez, Roberto (1948-) (belgyógyász, reumatológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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