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001-es BibID:	BIBFORM034571
Első szerző:	Kappelmayer János (laboratóriumi szakorvos)
Cím:	Progress in defining multidrug resistance in leukemia / Kappelmayer János, Simon Ágnes, Kiss Flóra, Hevessy Zsuzsa
Dátum:	2004
ISSN:	1473-7159
Megjegyzések:	Multidrug resistance (MDR) is a naturally occurring defense phenomenon by which cells battle against chemically foreign substances (xenobiotics), including some cytotoxic drugs. Membrane transporter hyperactivity is a major contributor to MDR and is the primary target of both diagnostic and therapeutic interventions. Multi-xenobiotic resistance can be exploited as several fluorescent indicator probes are extruded by the same drug transporters, making it possible to quantitatively measure MDR activity in cell lines and clinical samples by flow cytometry. The literature on MDR is reported in a number of different formats, making it difficult to compare data from various groups. This article will briefly review the pathomechanism, then focus upon the diagnostic approach, the interpretation of results from clinical samples and correlations with other variables. The authors believe that a standardized MDR assay, as well as a suitable monitoring test, may become a prognostic marker in several types of leukemia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Expert Review Of Molecular Diagnostics. - 4 : 2 (2004), p. 209-217. -
További szerzők:	Simon Ágnes (1969-) (laboratóriumi szakorvos) Kiss Flóra (1980-) (bőrgyógyász) Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos)
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