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001-es BibID:	BIBFORM035323
035-os BibID:	PMID:15205715
Első szerző:	Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:	Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women / H. P. Bhattoa, P. Bettembuk, S. Ganacharya, A. Balogh
Dátum:	2004
ISSN:	0937941X
Megjegyzések:	Hypovitaminosis D can result in low bone mass. The prevalence of hypovitaminosis D has public health implications, especially where data are lacking. Since diet and sunlight are the two souces of vitamin D, the results obtained in one geographical region may not be universally applicable. The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. We determined serum levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), degradation products of C-terminal telopeptides of type-I collagen (CTx), dietary calcium intake and BMD at L2-L4 lumbar spine (LS) and femur neck (FN) in 319 randomly selected ambulatory postmenopausal women. The prevalence of hypovitaminosis D (serum 25-OH-D ?ë♯n 50 nmol/1) was 56.7%. On comparing patients with normal and low 25-OH-D, a significant difference was found in age (61.6 ?? 8.5 years versus 67.3 ?? 9.9 years; P < 0.001), PTH (3.9 ?? 1.9 pmol/l versus 4.3 ?? 2.7 pmol/l; P < 0.05), FN BMD (0.802 ?? 0.123 g/cm2 versus 0.744 ?? 0.125 g/cm2; P < 0.001) and dietary calcium intake (714.4 ?? 199.4 g/day versus 607.9 ?? 233 g/day; P < 0.001). Osteoporotic patients had a significantly lower 25-OH-D (37.6 ?? 19.8 nmol/l versus 56.4 ?? 24 nmol/l; P < 0.001) and dietary calcium intake (519.2 ?? 244.5 mg/day versus 718.2 ?? 164.3 mg/day; P < 0.001). After controlling for all other variables, 25-OH-D was found to be significantly associated with age, the average hours of sunshine in the 3 months prior to 25-OH-D level determination and dietary calcium intake (r2 = 0. 190; P < 0.001). For FN BMD, significant independent predictors were age, body mass index, 25-OH-D and dietary calcium intake (r2 = 0.435; P < 0.001). The prevalence of hypovitaminosis D during spring, summer, autumn and winter was 71%, 46.3%, 49.4% and 56.7%, respectively. There was significant seasonal variation in 25-OH-D, PTH, OC, calcium intake and FN BMD. There is a high prevalence of hypovitaminosis D in healthy postmenopausal Hungarian women, and FN BMD is associated with serum 25-OH-D and dietary calcium intake.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Biochemical markers of bone turnover Bone mineral density Hypovitaminosis D Postmenopausal Seasonal variation 25 hydroxyvitamin D calcium carboxy terminal telopeptide collagen type 1 osteocalcin parathyroid hormone vitamin D adult aged article autumn bone mass bone metabolism bone turnover calcium intake community controlled study dietary intake female femur neck geographic distribution human Hungary lumbar spine major clinical study osteoporosis postmenopause prevalence priority journal public health seasonal variation spring summer sunlight vitamin D deficiency winter Adult Aged Aged, 80 and over Biological Markers Bone and Bones Bone Density Calcium Collagen Collagen Type I Diet Female Femur Neck Humans Hungary Middle Aged Osteocalcin Parathyroid Hormone Peptides Postmenopause Prevalence Seasons Vitamin D Vitamin D Deficiency egyetemen (Magyarországon) készült közlemény
Megjelenés:	Osteoporosis International. - 15 : 6 (2004), p. 447-451. -
További szerzők:	Bettembuk Péter Ganacharya, Sanjay Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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