Találati lista | Tudóstér

001-es BibID:	BIBFORM036298
035-os BibID:	PMID:15966211
Első szerző:	Lakatos Péter (Semmelweis Egyetem)
Cím:	Clinical presentation of Crohn's disease : association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery / Peter Laszlo Lakatos, Ferenc Szalay, Zsolt Tulassay, Tamas Molnar, Agota Kovacs, Beata Gasztonyi, Janos Papp, the Hungarian IBD Study Group, Laszlo Lakatos
Dátum:	2005
ISSN:	0172-6390
Megjegyzések:	Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population. METHODOLOGY: 564 CD patients (m/f: 278/286, age: 37.4 (SD 12.7) yrs, duration: 8.4 (7.1) yrs) were included. Disease phenotype was determined according to Vienna classification. Familial disease, extraintestinal manifestations (EIM), need for surgery and smoking habits were also analyzed. RESULTS: Familial IBD was present in 73 (12.9%) patients. Age at onset and presence of EIMs was associated with familial disease. Penetrating (44.6% vs. <10 yrs: 29.1%, P<0.0001) and ileocolonic disease (54.4% vs. 42.8%, P=0.03) were more common in patients with a disease duration of > or =10 yrs. In a logistic regression model female gender, colonic/ileocolonic location, smoking and familial IBD were independent risk factors for EIMs, while ileal and non-inflammatory disease increased the risk for resections. Smoking was also associated with frequent relapses. CONCLUSIONS: Familial IBD was associated with the presence of EIMs, while ileal involvement and noninflammatory behavior independently increased the risk for surgery. Since penetrating and extensive disease was more frequent in patients with longer disease duration our data support a possible change in location and behavior during the course of disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Hepato-Gastroenterology. - 52 : 63 (2005), p. 817-822. -
További szerzők:	Szalay Ferenc (belgyógyász) Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Molnár Tamás (orvos Szeged) Kovács Ágota Gasztonyi Beáta Papp János (Budapest) Lakatos László (Veszprém) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) The Hungarian IBD Study Group
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: