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001-es BibID:	BIBFORM036331
Első szerző:	Kovács Márta
Cím:	Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease (IBD) / Kovacs Marta, Lakatos Peter Laszlo, Papp Maria, Jacobsen Silvia, Nemes Eva, Polgar Marianne, Solyom Eniko, Bodi Piroska, Horvath Agnes, Muller Katalin Eszter, Molnar Kriszta, Szabo Doloresz, Cseh Aron, Dezsofi Antal, Arato Andras, Veres Gabor
Dátum:	2012
ISSN:	0277-2116
Megjegyzések:	Significance of pancreatic autoantibodies determined by using exocrine pancreas (PAB) and recombinant pancreas antigens (rPAB), as well as importance of autoantibodies against goblet cells (GAB) are not known in pediatric patients with inflammatory bowel disease (IBD). Our aim was to determine the complex analysis of PAB, rPAB, GAB, antibodies against Saccharomyces cerevisiae (ASCA), and perinuclear components of neutrophils (pANCA) in pediatric IBD patients. Moreover, association with NOD2/CARD15 and disease phenotype was determined. METHODS: 152 pediatric patients (median age 13.9 years) with IBD [103 patients with Crohn's disease (CD) and 49 patients with ulcerative colitis (UC)] and 104 controls were included. Serum autoantibodies were determined by indirect immunofluorescens assay. NOD2/CARD15 variants were tested by polymerase chain reaction/restriction fragment length polymorphism. RESULTS: The presence of PAB and rPAB was significantly higher in CD (34% and 35.9%) and in UC (20.4% and 24.5%) compared to pediatric control cohort (0% and 0%, p < 0.0001). In addition, GAB positivity was significantly increased in patients with UC in comparison to CD and controls, respectively (UC, 12.2%, CD, 1.9%, controls, 1.9%, p=0.02). Specificity of PAB and rPAB was 100%, however, sensitivity was low. The combination of PAB and/or ASCA/pANCA improved the sensitivity of serological markers in CD (87.4%) and in UC (79.6%); specificities were 89.3% and 93.2%, respectively. Pancreatic autoantibodies (PAB, rPAB) and GAB were not related to clinical presentation, medical therapy or need for surgery in CD or in UC. CONCLUSIONS: Pancreatic autoantibodies and GAB were specific for IBD but the sensitivity was limited as well as there was lack of correlation with clinical phenotype. Combinations of these antibodies have shown increased sensitivity, therefore, it may be recommended in the diagnostic procedure of IBD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition 55 : 4 (2012), p. 429-435. -
További szerzők:	Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Jacobsen, Silvia Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Polgár Marianna Sólyom Enikő Bodi Piroska Horváth Ágnes (Veszprém) Müller Katalin Eszter Molnár Kriszta Szabó Dolóresz Cseh Áron Dezsőfi Antal Arató András Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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