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001-es BibID:	BIBFORM036779
035-os BibID:	PMID:9138961
Első szerző:	Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:	HPV- and node status in cervical cancer long-term results / R. Póka, J. Czeglédy
Dátum:	1997
ISSN:	0301-2115 (Linking)
Megjegyzések:	OBJECTIVE: To evaluate prognostic significance of HPV-status in cervical cancerand to compare that with the prognostic significance of lymph-node status.METHODS: Cervical cancer biopsy specimens from primaries and, in surgical cases,from pelvic lymph-nodes too were analysed for the presence of humanpapillomavirus type 16 DNA-sequences using PCR technique. The management ofsurgical cases with two exceptions included Wertheim's hysterectomy predominantlywith preoperative local radiotherapy and also with postoperative local andexternal beam radiotherapy depending on the histology. Non-surgical cases weretreated with combined local and external radiotherapy to pelvic fields. RESULTS:Patients have been followed up for an average of 37 months after treatmentranging between 0 and 102 months. The mean progression-free survival time ofsurgical and non-surgical cases were 43 and 28 months, respectively. Patientswith HPV-16 positive biopsies from the cervical primary had an averageprogression-free survival of 37 months, the same as those with HPV-16 negativecervical biopsies. Those patients who were found to carry HPV-16 DNA in theirsurgically removed pelvic lymph-nodes had an average of 27 monthsprogression-free survival. The mean progression-free survival amonghistologically node-positive and node-negative surgical cases were 23 and 42months, respectively. The mean progression-free survival time of node-positivecases with HPV-16 positive cervical primary was 7.5 months while that of patientswith HPV-16 negative cervical biopsy was 38 months. Among histologicallynode-negative patients, HPV-16 positive and negative cases had an averageprogression-free survival time of 38 and 46 months, respectively. CONCLUSIONS:Among those under investigation the most important factors to predictprogression-free survival were surgically amenable disease, histologicallynegative pelvic lymph-nodes and HPV-16 negative cervical biopsies, though thislatter one proved significant only among surgical cases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Combined Modality Therapy Disease-Free Survival Female Follow-Up Studies Humans Lymphatic Metastasis Neoplasm Staging Papillomaviridae/isolation & purification Prognosis Uterine Cervical Neoplasms/mortality/pathology/surgery/virology egyetemen (Magyarországon) készült közlemény
Megjelenés:	European journal of obstetrics, gynecology, and reproductive biology. - 71 : 2 (1997), p. 169-172. -
További szerzők:	Czeglédy Judit (1944-) (virológus)
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