Találati lista | Tudóstér

001-es BibID:	BIBFORM036824
Első szerző:	Emri Eszter (Ph.D hallgató)
Cím:	Correlation among metallothionein expression, intratumoural macrophage infiltration and the risk of metastasis in human cutaneous malignant melanoma / E. Emri, K. Egervari, T. Varvölgyi, D. Rozsa, E. Miko, B. Dezső, I. Veres, G. Mehes, G. Emri, E. Remenyik
Dátum:	2013
ISSN:	0926-9959
Megjegyzések:	Background: The formation of metastases and the efficacy of systemic therapies in cutaneous malignant melanoma (CMM) depend on the characteristics of the tumour cells and the host immune response. Aberrant expression of metallothionein (MT) has been observed in several types of cancers with poor prognoses. Objective: To perform an immunohistochemical study on primary CMM comparing the MT expression of tumours without metastases (n = 23) to that of samples with haematogenous metastases (n = 23) and to examine the correlation between MT staining and immunological markers relevant in CMM progression. Methods: The immunohistochemical labelling of different tumour sections was analysed using tissue microarrays for the evaluation of the suitability of this method in future studies. Results: Our results suggest that MT overexpression is significantly more frequent in primary CMM with haematogenous metastases (P = 0.018) and that the overexpression is independent of the Breslow tumour thickness (R = 0.102, P = 0.501). Interestingly, MT overexpression of the tumour cells was correlated with the presence of tumour-infiltrating CD68(+) macrophages (P = 0.003), a known predictive factor for melanoma progression, thereby suggesting a role for MT in the development of a defective host immune response. Furthermore, the presence of CD163(+) macrophages infiltrating the tumours correlated with metastasis formation (P < 0.001), whereas the presence CD1a(+) dendritic cells surrounding the tumours was associated with a lower risk of haematogenous spread (P = 0.003). Conclusion: Our results demonstrate that MT may represent a suitable prognostic factor that can characterize the metastasising ability of CMM and the tumour-promoting host immune response.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány
Megjelenés:	Journal of The European Academy of Dermatology and Venereology. - 27 : 3 (2013), p. e320-e327. -
További szerzők:	Egervári Kristóf (1983-) (patológus) Várvölgyi Tünde (1984-) (bőrgyógyász) Rózsa Dávid (1982-) (Ph.D hallgató) Mikó Edit (1980-) (biológus) Dezső Balázs (1951-) (pathológus) Veres Imre (1963-) (bőrgyógyász) Méhes Gábor (1966-) (patológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Remenyik Éva (1956-) (bőrgyógyász)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Az UV fény DNS károsító hatásának in vitro vizsgálata K68401 OTKA TÁMOP-4.2.2.-08/1-2008-0019 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: