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001-es BibID:	BIBFORM037169
Első szerző:	Keresztesi Edina (biokémikus, molekuláris biológus)
Cím:	Adenosine As A Mediator Of The Antiinflammatory Effects Of Apoptotic Cell Uptake / Edina Keresztesi, Krisztina Köröskényi, László Fésüs, Zsuzsa Szondy
Dátum:	2012
Megjegyzések:	It is well known that the apoptotic cell uptake inhibits inflammatory response in macrophages. This inhibition is mediated directly via cell surface receptors or by soluble mediators release by macrophages engulfing apoptotic cells. Adenosine is an endogenous anti-inflammatory mediator. The different adenosine receptor subtypes (A1, A2A, A2B, A3) - which all can be found on macrophages - are all seven transmembrane and G-protein coupled receptor. These are further classified based on their ability to either stimulate or inhibit the adenylate cyclase activity. While the A2A and A2B receptors are coupled to Gs and mediate the stimulation of adenylate cyclase; the A1 and A3 are coupled to Gi and inhibit the adenylate cyclase activity. Previous studies in our laboratory have shown that adenosine is released by macrophages engulfing apoptotic cells and inhibits the secretion of neutrophil chemoattractant factors (i.g. MIP-2, KC) which otherwise would be produced following apoptotic cell exposure by stimulating the A2A receptor ? adenylate cyclase pathway. (Köröskényi et. al. The Journal of Immunology June 15, 2011) The aim of the present study was to test the effect of the loss of adenosine A3 receptor on the proinflammatory cytokine production of macrophages following apoptotic cell uptake.
ISBN:	978-953-95551-4-4
Tárgyszavak:	Természettudományok Biológiai tudományok előadáskivonat adenosine A3 receptor
Megjelenés:	FEBS3 + Meeting From molecules to life and back, Book of abstracts / eds. Jerka Dumic, Zrinka Kovarik, Jadranka Varljen. - p. 205. -
További szerzők:	Köröskényi Krisztina (1979-) (biokémikus, molekuláris biológus) Fésüs László (1947-) (orvos biokémikus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:	TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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