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001-es BibID:	BIBFORM037173
Első szerző:	Kőszegi Zsolt (kardiológus, belgyógyász)
Cím:	Calculation the Translesional Pressure Gradients on Coronary Stenosis by Combining Three-dimensional Coronary Angiography Parameters with Frame Count Data / Kőszegi Zs., Tar B., Ember S., Lugosi P., Béres Z., Sánta J., Sváb M., Bakk S., Kolozsvári R., Polgár P.
Dátum:	2011
Megjegyzések:	Background: Assessing the hemodynamic impact of anintermediate coronary artery stenosis on the basis of thediameter stenosis is often ambiguous. Measurement of thefractional flow reserve (FFR) is necessary in these casesfor correct clinical decision making.Aim: Determining the tranlesional pressure gradients,based on the data calculated from the 3D coronaryangiography and the frame count method using classicfluid dynamic equations and to compare them with themeasured values.Methods: FFR measurements were performed on 15coronary segments of 10 patients by PressureWire?Certus. 3D reconstructions of the same segments wereperformed by the IC30 software (Siemens), and the crosssectionalarea stenosis (AS) (%), the length of the lesion(L) (mm), the minimal lumen area (MLA) (mm2), theplaque volume (PV) (%) and the distal reference area(dRefA) (mm2) were determined. The flow velocity (mm/s)was assessed by the frame count on the coronaryangiography following administration of 6 ml contrastmaterial with a 3ml/s rate by ACIST? Injection System(BBraun). Vessel length was determined on the 3Dreconstruction. Pressure gradients (Hgmm) werecalculated on the basis of the fluid dynamic equations:dP= Q(Rp+QRt), where Rp= 0,75 x L / MLA2and Rt = 3,76x (1/MLA - 1/dRef A)2,Q(volumetric flow)(ml/s) = flow velocity x dRefA.Results: Regression analysis has demonstratedsignificant relationship between the calculated andmeasured resting distal/proximal pressure ratio (r=0.66;p=0.007). Tight correlation has been found between thecalculated and measured FFR (assuming twofoldvolumetric flow during vasodilatation) (r=0.88;p<0.001). Among the 3D parameters only the AS and thePV showed significant correlation with the FFR (r=0.62and 0.71; p=0.013 and 0.003, respectively).Conclusions: The calculation of pressure gradients byfluid dynamic equations using 3D coronary angiographyand frame count data can predict the functional flowconsequence of a stenosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban FFR measurements IC30 software
Megjelenés:	Computing in Cardiology [electronic resource]. - 38 (2011), p. 729-732. -
További szerzők:	Tar B. Ember Sándor Lugosi P. Béres Z. Sánta J. Sváb Marianna Bakk Sándor Kolozsvári Rudolf (1976-) (kardiológus) Polgár Péter
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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