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001-es BibID:	BIBFORM037482
Első szerző:	Zsóri Katalin Szilvia
Cím:	Vitamin B12 level in peripheral arterial disease / Zsóri Katalin S., Csiki Zoltán, Katona Éva, Bereczky Zsuzsanna, Shemirani Amir-Houshang
Dátum:	2013
ISSN:	0929-5305
Megjegyzések:	Hyperhomocysteinemia is considered a risk factor for atherosclerosis. Methyltetrahydrofolate reductase (MTHFR) gene mutation and low level of plasma vitamin B(12) and folate could take part in the etiology of peripheral arterial disease (PAD). We examined whether plasma vitamin B(12) and folate levels and MTHFR-C677T polymorphism are associated with the risk of PAD. The study comprised 293 patients (107 females, 186 males, mean age of 66 ? SEM0.7 years) and 293 sex-matched control subjects (mean age of 62 ? SEM0.8 years). We also determined plasma lipid profile, hs-CRP, creatinine, vitamin B(12), folate and total homocysteine (tHcy) for all patients and controls. Odds ratios were non-significant for different genotypes of MTHFR-C677T polymorphism. There was a significant lower level of vitamin B(12) in PAD patients. 43 and 25 % of patient and control populations were in the lowest quartile of vitamin B(12) (<188 pmol/L), respectively. Plasma level of vitamin B(12) in the lowest quartile significantly increased tHcy level in PAD patients, and it was independent of plasma folate level. Low level of plasma vitamin B(12) was independently associated with hyperhomocysteinemia in PAD patients. The prevalence of the MTHFR-C677T mutation was not significantly different in patients with PAD compared with controls.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Folate Methyltetrahydrofolate reductase Peripheral arterial disease Vitamin B12
Megjelenés:	Journal Of Thrombosis And Thrombolysis. - 36 : 1 (2013), p. 77-83. -
További szerzők:	Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Katona Éva (1961-) (klinikai biokémikus) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Shemirani, Amir-Houshang (1971-) (kutató orvos, laboratórium szakorvos)
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