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001-es BibID:	BIBFORM037920
Első szerző:	Kalantari, Heybatullah
Cím:	Protective effect of Cassia fistula fruit extract against bromobenzene-induced liver injury in mice / Kalantari, H., Jalali, M., Jalali, A., Mahdavinia, M., Salimi, A., Juhasz, B., Tosaki, A., Gesztelyi, R.
Dátum:	2011
ISSN:	0960-3271
Megjegyzések:	In the present study, hepatoprotective effect of Cassia fistula fruit extract was investigated in mice. Animals were divided into six groups receiving normal saline (1), bromobenzene (460 mg/kg) alone (2) and together with increasing doses (200, 400, 600, 800 mg/kg) of a crude hydro-alcoholic extract of Cassia fistula fruit (3-6, respectively). All administrations were carried out orally, daily, for 10 days. On the 11th day, animals were sacrificed. Serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (?GT) were determined; serum levels of direct and total bilirubin were measured; furthermore, livers were prepared for histological examination. Our results showed that bromobenzene treatment alone elicited a significant increase in activities of AST, ALT, ALP (but not ?GT), and it significantly elevated the levels of direct and total bilirubin. Co-treatment with Cassia fistula fruit extract, however, significantly and dose-dependently decreased the above-mentioned enzyme activities (with exception of ?GT) and bilirubin levels, producing a recovery to the naive state. The protective effect of Cassia fistula fruit extract against liver injury evoked by bromobenzene was confirmed by histological examination as well. In conclusion, the Cassia fistula fruit extract has significant hepatoprotective effect in our murine model.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban hepatic toxicology Cassia fistula bromobenzene
Megjelenés:	Human & Experimental Toxicology. - 30 : 8 (2011), p. 1039-1044. -
További szerzők:	Jalali, Mohammadtaha Jalali, Amir Mahdavinia, M. Salimi, Abobakr Juhász Béla (1978-) (kísérletes farmakológus) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:	78223 OTKA 72315 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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