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001-es BibID:	BIBFORM038477
Első szerző:	Módis László (szemész szakorvos, kontaktológus)
Cím:	Distribution of antioxidant enzymes in the normal aged human conjunctiva : an immunocytochemical study / Módis László, Marshall George E., Lee William R.
Dátum:	1998
ISSN:	0721-832X
Megjegyzések:	Background: The pur- pose of the study was to map the precise location of four antioxidant enzymes in the normal human con- junctiva. Methods: Conjunctival tissue (seventeen specimens) from seven patients was processed for light microscopy and immunogold electron microscopy. Antibodies were used to label glutathione peroxidase, gluta- thione S-transferase (acidic and neu- tral forms) and copper/zinc superox- ide dismutase. Results: All layers of the epithelium exhibited labelling for all four enzymes, although there were differences in labelling intensi- ties and distribution between the en- zymes. Wing cells showed more in- tense labelling for glutathione perox- idase, glutathione S-transferase (neu- tral form) and copper/zinc superoxide dismutase than did basal and super- ficial cells. The strongest immunore- activity was detected for glutathione S-transferase (acidic) and was equal- ly strong in the superficial and wing cells. Wing cells demonstrated more immunoreactivity in the cell nuclei with antibodies against all four en- zymes. A high degree of labelling was also observed in the microplicae and actin cortex of the superficial cells. Leukocytes, fibroblasts, endo- thelial cells and erythrocytes within the stroma exhibited minimal label- ling. Conclusion: The subtle changes in distribution of antioxidant enzymes in the normal human con- junctival epithelium most probably reflect exposure to free radicals in the tear film and are based on the dif- ferent proliferative and functional activities of each of the anatomical layers.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Graefes Archive For Clinical And Experimental Ophthalmology. - 236 : 2 (1998), p. 86-90. -
További szerzők:	Marshall, George E. Lee, William R.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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