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001-es BibID:BIBFORM038563
Első szerző:Kávai Mária (vegyész)
Cím:Defective immune complex degradation by monocytes in patients with systemic lupuserythematosus / Kavai M., Csipo I., Sonkoly, I., Csongor J., Szegedi Gy.
Dátum:1986
ISSN:0300-9475
Megjegyzések:The binding of 125I-labelled anti-bovine serum albumin (BSA)-BSA immune complexes(IC), giving a final molar antibody to antigen ratio of 1:1, to monocytesisolated from 18 patients with systemic lupus erythematosus (SLE) and from 10normal healthy donors was quantitatively investigated. The degradation of thebound IC by the same monocytes was kinetically determined at the same time. Theassays were performed on monocyte monolayers. Scatchard plots at 4 degrees Cdemonstrated that monocytes from patients with active SLE expressed a mean Fcgamma receptor (FcR) number that was 22% higher than that of the controls,although this did not reach statistical significance. The FcR number of normalmonocytes and the degradation rate of anti-BSA-BSA complexes by the same cellsshowed a positive correlation. At the same time, the digestion of anti-BSA-BSAcomplexes by monocytes of SLE patients with active disease was prolonged, despitetheir enhanced FcR-ligand binding. The dissociation of FcR-ligand binding andFcR-mediated degradation suggests that the IC degradation is controlled byaltered biochemical mechanisms in the monocytes of SLE patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Scandinavian Journal Of Immunology. - 24 : 5 (1986), p. 527-532. -
További szerzők:Csípő István (1953-) (vegyész) Sonkoly Ildikó Csongor József Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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