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001-es BibID:	BIBFORM038614
035-os BibID:	PMID:9696432
Első szerző:	Kiss Emese (belgyógyász, immunológus)
Cím:	Recombinant human erythropoietin modulates erythrocyte complement receptor 1 functional activity in patients with lupus nephritis / E. Kiss, M. Kávai, I. Csípő, Gy. Szegedi
Dátum:	1998
ISSN:	0301-0430
Megjegyzések:	Deposition of immune complexes (IC) is an important step in the pathogenesis oflupus nephritis. Impairment of IC-clearance contributes to the accumulation ofIC. It may be partly attributed to decreased complement containing immune complex(ICC) binding by erythrocytic complement receptor 1 (ECR1). Stimulatingerythropoiesis with recombinant human erythropoietin (rHuEPO) may enhance theIC-clearance as increasing ECR1 expression and/or functional activity. Ten anemicpatients with lupus nephritis were treated with 50 IU rHuEPO (Eprex) per kg bodyweight three times a week during a five week period. ICC-binding capacity of ECR1was determined with 125I-labelled, C3ib containing BSA-anti-BSA complexes. Inaddition to effective correction of anemia, indicated by increased red blood cellcount (RBC), hemoglobin concentration and reticulocyte ratio, rHuEPOsignificantly improved decreased ECR1 functional (ICC-binding) activity inpatients with lupus nephritis. This improvement correlated with the increase inreticulocyte ratio. Although patients were kept on their previous therapy duringEprex administration, their clinical condition also improved. That was shown by adecrease in Westergreen ratio, serum creatinine concentration and anti-dsDNAlevel and also by an increase in creatinine clearance. Results suggest abeneficial immune modulatory effect of rHuEPO in lupus nephritis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical Nephrology. - 49 : 6 (1998), p. 364-369. -
További szerzők:	Kávai Mária (1930-) (vegyész) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Csípő István (1953-) (vegyész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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