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001-es BibID:	BIBFORM038628
035-os BibID:	PMID:9161700
Első szerző:	Kiss Emese (belgyógyász, immunológus)
Cím:	CR1 density polymorphism and expression on erythrocytes of patients with systemic lupus erythematosus / Kiss E., Csipő I., Cohen J. H., Reveil B., Kávai M., Szegedi Gy.
Dátum:	1996
ISSN:	0891-6934
Megjegyzések:	The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomic DNA fragment of 1.8 kb separated by HindIII endonuclease digestion and agarose gel electrophoresis. Our data supported the earlier results that the number of binding sites/E for monoclonal anti-CR1 decreased among SLE patients compared with normal individuals having the same alleles for the CR1/E density. At the same time the novelty of our recent results was that the decreased expression of CR1 on E correlated significantly with kidney involvement in patients homozygous for the CR1/E high density allele (HH). These data suggest that the deficiency of the detectable number of CR1 on erythrocytes is acquired in this SLE population.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény 0 (Receptors, Complement) 0 (Receptors, Complement 3b) Erythrocytes/chemistry/immunology Female Genotype Heterozygote Homozygote Humans Lupus Erythematosus, Systemic/genetics/metabolism/pathology Male Polymorphism, Genetic/genetics Polymorphism, Restriction Fragment Length Receptors, Complement/genetics Receptors, Complement 3b/biosynthesis/genetics/immunology Severity of Illness Index
Megjelenés:	Autoimmunity. - 25 : 1 (1996), p. 53-58. -
További szerzők:	Cohen, J. H. M. Reveil, B. Kávai Mária (1930-) (vegyész) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Csípő István (1953-) (vegyész)
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