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001-es BibID:	BIBFORM038629
035-os BibID:	PMID:9272279
Első szerző:	Csípő István (vegyész)
Cím:	Serum complement activation of SLE patients during plasmapheresis / Csipő I., Kávai M., Kiss E., Bedő Z., Csongor J., Szegedi Gy., Philbert F., Cohen J. H.
Dátum:	1997
ISSN:	0891-6934
Megjegyzések:	The erythrocyte complement receptor 1 (ECR1)-immune complex binding assay is a sensitive method for the determination of complement fragments which can be activated by bovine serum albumin (BSA)-anti-BSA in vitro. When the C3b/C4b containing bovine serum albumin (BSA)-anti-BSA was formed in the presence of the serum of patients with systemic lupus erythematosus (SLE) its binding to ECR1 was found to be lower than that formed in sera of normal volunteers. The plasmapheresis of SLE patients homozygous for the CR1/E high density allele displays a beneficial effect on the formation of C3b/C4b containing BSA-anti-BSA and its binding to ECR1. There was no significant correlation between the serum C3/C4 level and the percentage of C3b/C4b containing BSA-anti-BSA binding to the ECR1 of SLE patients during plasmapheresis. At the same time, there was an inverse correlation between the serum immune complex level and the ECR1 binding, which was significant in 3 of 5 cases. These data suggest that, besides the determination of different components of complement activation, the functional assay of complement activation might be useful in monitoring the effect of plasmapheresis in SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény 0 (Antibodies) 0 (Antigen-Antibody Complex) 0 (Receptors, Complement 3b) 0 (Serum Albumin, Bovine) 80295-43-8 (Complement C3b) 80295-50-7 (Complement C4b) Adult Animals Antibodies/immunology Antigen-Antibody Complex/blood Cattle Complement Activation/immunology Complement C3b/immunology Complement C4b/immunology Erythrocytes/immunology Female Humans Lupus Erythematosus, Systemic/blood/immunology Male Middle Aged Plasmapheresis Receptors, Complement 3b/immunology Serum Albumin, Bovine/immunology
Megjelenés:	Autoimmunity. - 25 : 3 (1997), p. 139-146. -
További szerzők:	Kávai Mária (1930-) (vegyész) Kiss Emese (1960-) (belgyógyász, immunológus) Bedő Zoltán Csongor József Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Philbert, F. Cohen, J. H. M.
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