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001-es BibID:	BIBFORM038886
035-os BibID:	PMID:11903236
Első szerző:	Farkas Beatrix
Cím:	Terbinafine (Lamisil) treatment of toenail onychomycosis in patients with insulin-dependent and non-insulin-dependent diabetes mellitus : a multicentre trial / B. Farkas, C. Paul, A. Dobozy, J. Hunyadi, A. Horvath, G. Fekete
Dátum:	2002
ISSN:	0007-0963
Megjegyzések:	bibEBI12921 újratöltveBackground Diabetes mellitus (DM) affects an estimated 175 million people world-wide.Approximately one-third of patients with DM have toenail onychomycosis.Objectives To determine the ef?cacy and safety of terbina?ne treatment of toenail onychomycosis inpatients with DM receiving insulin and ? or oral antidiabetic agents. Special interest was focused onpotential drug interactions with oral hypoglycaemic substances.Methods In a multicentre trial, patients suffering from insulin-dependent DM (IDDM) or noninsulin-dependent DM (NIDDM) with toenail onychomycosis were treated for 12 weeks with oralterbina?ne 250 mg daily and followed up to 48 weeks. In addition to clinical, mycological andlaboratory investigations, blood glucose levels were monitored.Results At the end of the trial (week 48), a mycological cure rate of 73% was achieved. The ratesof clinical cure and complete cure (mycological cure plus clinical cure) were 57% and 48%,respectively. There was no statistically signi?cant difference between the NIDDM and IDDM groupswith respect to the cure rates (P > 0á05). No hypoglycaemic episode was reported and none of thepatients had hypoglycaemia during the treatment phase.Conclusions With excellent cure rates and a good tolerability pro?le, terbina?ne should continue tobe a drug of choice for the treatment of
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	The British Journal of Dermatology. - 146 : 2 (2002), p. 254-260. -
További szerzők:	Paul, C. Dobozy A. Horváth A. Fekete G. Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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