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001-es BibID:	BIBFORM040258
Első szerző:	Beer, Lucian
Cím:	Continued mechanical ventilation during coronary artery bypass graft operation attenuates the systemic immune response / Lucian Beer, Tamás Szerafin, Andreas Mitterbauer, Tamás Debreceni, Tamás Maros, Martin Dworschak, Georg A. Roth, Hendrik Jan Ankersmit
Dátum:	2013
Megjegyzések:	OBJECTIVES: Cardiopulmonary bypass (CPB) is known to induce a short pro- and long-lasting anti-inflammatory immune response. The anti-inflammatory protein soluble ST2 (sST2) may be involved in the pathogenesis of postoperative immune dysfunction. We investigated whether continued mechanical ventilation during CPB has an impact on postoperative serum sST2 and cytokine release. METHODS: Thirty patients undergoing conventional coronary artery bypass graft (CABG) operation were randomized into a ventilated on CPB (VG; n = 15) and non-ventilated on CPB group (NVG; n = 15). Blood samples were drawn at the beginning and at the end of surgery, and at the 5 consecutive days. sST2, IL-4, IL-10, IgM, IgG, IL-6 and endotoxin were measured by ELISA. Data are given as mean standard deviation (SD). A Mann-Whitney U-test was used for statistical analysis. RESULTS: Serum levels of sST2 and IL-10 were significantly higher in the NVG when compared with the VG at the first postoperative day (POD-1) [sST2 pg/ml: 1366.4 (433) (VG) vs 2296.3 (1795.5) (NVG) P = 0.029; IL-10 pg/ml: 10.7 (4.0) (VG) vs 15.4 (6.8) (NVG) P = 0.038]. In addition, the secretion of proinflammatory IL-6 was slightly reduced in the VG at POD-1 [IL-6 pg/ml: 83.1 (52.5) (VG) vs 110.2 (42.3) (NVG) P = 0.033]. IL-4, endotoxin, IgM and IgG showed no differences between groups. CONCLUSION: These data suggest that continued mechanical ventilation during CABG attenuates inflammatory and anti-inflammatory immune responses after CPB. Continued mechanical ventilation may have beneficial effects in the attenuation of the CPB-induced immune activation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Cardio-Thoracic Surgery 44 : 2 (2013), p. 282-287. -
További szerzők:	Szerafin Tamás (1960-) (szívsebész, mellkassebész) Mitterbauer, Andreas Debreceni Tamás (1982-) (orvos) Maros Tamás Miklós (1969-) (szívsebész) Dworschak, Martin Roth, Georg Ankersmit, Hendrik Jan
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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