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001-es BibID:	BIBFORM040967
Első szerző:	Steiber Zita (orvos, szemész)
Cím:	Relationships between estradiol, progesterone, and plasminogen activator inhibitor longitudinally during normal human pregnancy / Steiber, Z., Silver, D. M., Tozser, J., Bagossi, P., Jakab, A., Berta, A., Csutak, A.
Dátum:	2012
ISSN:	1755-375X
Megjegyzések:	Purpose To investigate the hypothesis that the plasminogen activator proteolysis cascade in the eye is controlled locally instead of systemically. During pregnancy, systemic blood levels of estradiol (E2), progesterone (P4) and plasminogen activator inhibitors (PAI) are expected to rise with gestational age; is there a consequent rise in PAI normally present in tears? Methods PAI-2 levels were measured, using Imubind ELISA, longitudinally from three to four tear samples collected from each of 13 women between 8 and 36 weeks of pregnancy. During the same visits, blood samples were analyzed for PAI-2, E2 and P4. The analysis included successful results from 36 tear samples (PAI-2) and 45 blood samples (PAI-2, E2 and P4). Results Increases in blood levels of PAI-2, E2 and P4 occurred over the measured gestational period, significantly correlated with time and with each other (all R2>0.75). Tear levels of PAI-2 did not increase and were not correlated with gestation or blood PAI-2 (both R2<0.06). Conclusion Our finding is that tear PAI-2 levels are dissociated from the progression of pregnancy and the concommitant elevated systemic blood E2 and P4 hormone and PAI-2 levels, indicating the possibility of local control of proteolysis in the eye, perhaps due to a blood-brain barrier to the elevated systemic blood composition levels.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Acta Ophthalmologica. - 90 : S249 (2012), p. T001. -
További szerzők:	Silver, David M. Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Bagossi Péter (1966-2011) (biokémikus, vegyész) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Berta András (1955-) (szemész, gyermekszemész) Csutak Adrienne (1971-) (szemész)
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