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001-es BibID:	BIBFORM041254
035-os BibID:	PMID:22510271
Első szerző:	Hrabovszky Erik
Cím:	Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons / Erik Hrabovszky, Csilla S. Molnár, Robert Nagy, Barbara Vida, Beáta Á. Borsay, Kálmán Rácz, László Herczeg, Masahiko Watanabe, Imre Kalló, Zsolt Liposits
Dátum:	2012
ISSN:	0013-7227
Megjegyzések:	Amino acid (aa) neurotransmitters in synaptic afferents to hypothalamic GnRH-I neurons are critically involved in the neuroendocrine control of reproduction. Although in rodents the major aa neurotransmitter in these afferents is ?-aminobutyric acid (GABA), glutamatergic axons also innervate GnRH neurons directly. Our aim with the present study was to address the relative contribution of GABAergic and glutamatergic axons to the afferent control of human GnRH neurons. Formalin-fixed hypothalamic samples were obtained from adult male individuals (n = 8) at autopsies, and their coronal sections processed for dual-label immunohistochemical studies. GABAergic axons were labeled with vesicular inhibitory aa transporter antibodies, whereas glutamatergic axons were detected with antisera against the major vesicular glutamate transporter (VGLUT) isoforms, VGLUT1 and VGLUT2. The relative incidences of GABAergic and glutamatergic axonal appositions to GnRH-immunoreactive neurons were compared quantitatively in two regions, the infundibular and paraventricular nuclei. Results showed that GABAergic axons established the most frequently encountered type of axo-somatic apposition. Glutamatergic contacts occurred in significantly lower numbers, with similar contributions by their VGLUT1 and VGLUT2 subclasses. The innervation pattern was different on GnRH dendrites where the combined incidence of glutamatergic (VGLUT1 + VGLUT2) contacts slightly exceeded that of the GABAergic appositions. We conclude that GABA represents the major aa neurotransmitter in axo-somatic afferents to human GnRH neurons, whereas glutamatergic inputs occur somewhat more frequently than GABAergic inputs on GnRH dendrites. Unlike in rats, the GnRH system of the human receives innervation from the VGLUT1, in addition to the VGLUT2, subclass of glutamatergic neurons.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Endocrinology. - 153 : 6 (2012), p. 2766-2776. -
További szerzők:	Molnár Csilla S. (Budapest) Nagy Róbert (Budapest) Vida Barbara Borsay Beáta Á. (1982-) (igazságügyi orvosszakértő) Rácz Kálmán (1981-) (igazságügyi rezidens) Watanabe, Masahiko Kalló Imre Liposits Zsolt Herczeg László (1954-) (igazságügyi orvosszakértő)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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