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001-es BibID:	BIBFORM041298
035-os BibID:	PMID:9737719
Első szerző:	Monsonego, Alon
Cím:	Factor XIIIa as a nerve-associated transglutaminase / Alon Monsonego, Tal Mizrahi, Shoshana Eitan, Gila Moalem, Helga Bárdos, Róza Ádány, Michal Schwartz
Dátum:	1998
Megjegyzések:	Recent findings have led to changes in the traditional concept of nerve recovery, including the realization that injured nerves, like any other injured tissue, need the assistance of blood-derived cells and factors in order to heal. We show that factor XIIIa (FXIIIa, the potentially active a2subunit of factor XIII), an enzyme that participates in blood coagulation by stabilizing the fibrin clot, is also active in the nervous system where it may play a key role in the healing of injured tissue. We demonstrate that the plasma, macrophages and nerves of fish contain a 55 kDa form of transglutaminase that cross-reacts immunologically with the a-subunit of FXIII in mammals (80 kDa). The fish enzyme in the plasma, unlike its mammalian counterpart, is active, pointing to a difference in control of the coagulation pathway in the two species. Analysis of FXIIIa expression in mammalian neural tissues and their response to injury revealed high levels of the enzyme in media conditioned by peripheral nerves as compared with medium conditioned by nerves of the central nervous system. Furthermore, similarity was observed in the postinjury behavior of FXIIIa in regenerating nerve tissues (peripheral nervous system of mammals and the central nervous system of fish). We suggest that the postinjury level of factor XIIIa in the nervous system may be related to the tissue's regenerative capacity, and that FXIIIa may therefore be a link underlying a possible association between the processes of blood coagulation and nerve healing.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban FXIIIa thrombin CNS PNS nerve regeneration külföldön készült közlemény
Megjelenés:	FASEB Journal. - 12 : 12 (1998), p. 1163-1171. -
További szerzők:	Mizrahi, Tal Eitan, Shoshana Moalem, Gila Schwartz, Michal Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Bárdos Helga (1969-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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