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001-es BibID:	BIBFORM041414
035-os BibID:	PMID:2859670
Első szerző:	Muszbek László (haematológus, kutató orvos)
Cím:	Factor XIII of blood coagulation in human monocytes / L. Muszbek, R. Adany, Gy. Szegedi, J. Polgar, M. Kavai
Dátum:	1985
Megjegyzések:	The presence of Factor XIII subunit a was demonstrated in human monocytes by immunoperoxidase staining using specific antisera against Factor XIII and its subunits. This finding was verified by immunobiochemical techniques, as well. In an immunoblotting system after SDS polyacrylamide gel electrophoresis of denatured monocyte homogenate a protein band comigrating with Factor XIII subunit a showed positive reaction with antibodies against this subunit or whole Factor XIII. In contrast, no subunit b of Factor XIII could be detected by either of these methods in monocytes. Activity measurements were carried out by the dansylcadaverine incorporation assay in the absence and presence of anti-Factor XIII antibody with and without thrombin activation. The expression of transglutaminase activity required thrombin and was completely abolished in presence of anti- Factor XIII antibody, which clearly indicate that practically all the transglutaminase activity measured in monocytes comes from Factor XIII. Factor XIII of monocytes and macrophages might have a role in formation of focal fibrin thrombi as well as in organization of stable, fibrinolysis resistant fibrin clot at the site of inflammation or around tumor cells.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Factor XIII monocytes transglutaminase activity immunoblotting egyetemen (Magyarországon) készült közlemény
Megjelenés:	Thrombosis Research. - 37 : 3 (1985), p. 401-410. -
További szerzők:	Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Polgár János Kávai Mária (1930-) (vegyész) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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