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001-es BibID:	BIBFORM041514
Első szerző:	Samuelov, Liat
Cím:	Topobiology of Human Pigmentation : P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis / Samuelov Liat, Sprecher Eli, Sugawara Koji, Singh Suman K., Tobin Desmond J., Tsuruta Daisuke, Bíró Tamás, Kloepper Jennifer E., Paus Ralf
Dátum:	2013
ISSN:	0022-202X
Megjegyzések:	P-cadherin serves as a major topobiological cue in mammalian epithelium. In human hair follicles (HFs), it is prominently expressed in the inner hair matrix that harbors the HF pigmentary unit. However, the role of P-cadherin in normal human pigmentation remains unknown. Since patients with mutations in the gene that encodes P-cadherin show hypotrichosis and fair hair, we explored the hypothesis that P-cadherin may control HF pigmentation. When P-cadherin was silenced in melanogenically active organ-cultured human scalp HFs, this significantly reduced HF melanogenesis and tyrosinase activity as well as gene and/or protein expression of gp100, stem cell factor, c-Kit, and microphthalmia-associated transcription factor (MITF), both in situ and in isolated human HF melanocytes. Instead, epidermal pigmentation was unaffected by P-cadherin knockdown in organ-cultured human skin. In hair matrix keratinocytes, P-cadherin silencing reduced plasma membrane ?-catenin, while glycogen synthase kinase 3 beta (GSK3?) and phospho-?-catenin expression were significantly upregulated. This suggests that P-cadherin-GSK3?/Wnt signaling is required for maintaining expression of MITF to sustain intrafollicular melanogenesis. Thus, P-cadherin-mediated signaling is a melanocyte subtype-specific topobiological regulator of normal human pigmentation, possibly via GSK3?-mediated canonical Wnt signaling
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Investigative Dermatology. - 133 : 6 (2013), p. 1591-1600. -
További szerzők:	Sprecher, Eli Sugawara, Koji Singh, Suman K. Tobin, Desmund J. Tsuruta, Daisuke Bíró Tamás (1968-) (élettanász) Kloepper, Jennifer E. Paus, Ralf
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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