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001-es BibID:	BIBFORM041717
035-os BibID:	PMID:16240671
Első szerző:	Rakotovao, Andry
Cím:	Selenium status as determinant of connexin-43 dephosphorylation in ex vivo ischemic/reperfused rat myocardium / Andry Rakotovao, Stéphane Tanguy, Marie-Claire Toufektsian, Corinne Berthonneche, Véronique Ducros, Arpad Tosaki, Joël de Leiris, François Boucher
Dátum:	2005
Megjegyzések:	Recent studies have demonstrated that electrical uncoupling at gap junctions during ischemia is associated with cardiac Connexin-43 (Cx43) dephosphorylation. Whether oxidative stress is involved in this phenomenon still remains unclear. In the present study, we examined the influence of selenium intake on reperfusion-induced Cx43 dephosphorylation. Male Wistar rats were fed a diet containing either 0.05 mg/kg (Low-Se, n = 13) or 1.5 mg/kg (High-Se, n = 11) selenium for 8 weeks. At the end of this diet, hearts were isolated and subjected to 10 min regional ischemia followed by 10 min reperfusion. The level of dephosphorylated Cx43 was determined in tissue samples from ischemic/reperfused and non-ischemic regions of the hearts. At the end of the experiemental diet, the activity of the antioxidant enzyme glutathione peroxidase (GSH-Px) was increased in high-Se hearts compared with low-Se hearts (+ 13%; p < 0.05). After ischemia/reperfusion, in low-Se hearts, Cx43 dephosphorylation appeared significantly increased in the left ventricle compared to the non-ischemic right ventricle (+ 149%; p < 0.05). The high-Se diet significantly reduced Cx43 dephosphorylation in the left ventricle (p < 0.05 vs. low-Se diet). In conclusion, our results suggest that oxidative stress may be involved in Cx43 dephosphorylation during myocardial ischemia/reperfusion, thereby contributing to arrhythmogenesis.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Journal of Trace Elements in Medicine and Biology 19 : 1 (2005), p. 43-47. -
További szerzők:	Tanguy, Stéphane Toufektsian, Marie-Claire Berthonneche, Corinne Ducros, Véronique Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) de Leiris, Joel Boucher, Francois
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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