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001-es BibID:	BIBFORM042119
Első szerző:	Bíró Tamás (élettanász)
Cím:	TRP Channels in Cutaneous Biology in Health and Disease / Biro Tamas, Paus, Ralf
Dátum:	2011
Megjegyzések:	Recent research progress has revealed that numerous transient receptor potential (TRP) channels are not only expressed on sensory afferent endings in human and murine skin, but, intriguingly, also on various non-neuronal skin cell populations such as mast cells, keratinocytes, and sebocytes. These TRP channels have now become implicated in an increasing variety of cutaneous functions. In this chapter, we focus on delineating the physiological regulatory function of TRP channels in skin-derived pruritus (pruritoceptive itch) and in the control of proliferation, differentiation, apoptosis, and cytokine/mediator production of various cell types of the skin and its appendages (e.g. hair follicle, sebaceous gland). Moreover, we discuss the emerging evidence that selected TRP channels are also involved in skin diseases, such as e.g. in skin carcinogenesis and skin tumor growth, acne, seborrhea, psoriasis, and hair growth disorders. We close by delineating some important future basic and clinical research directions and strategies that are geared towards the therapeutic targeting of defined TRP channels for the management of skin disorders.
ISBN:	978 1 61668 337 5
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet TRP channels Cutaneous Biology
Megjelenés:	TRP Channels in Health and Disease : Implications for Diagnosis and Therapy / ed. Arpad Szallasi. - p. 331-361. -
További szerzők:	Paus, Ralf
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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