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001-es BibID:	BIBFORM042504
035-os BibID:	PMID:3588164
Első szerző:	Balogh Ádám (szülész-nőgyógyász, endokrinológus szakorvos)
Cím:	Clinical and endocrine effects of long-term hormonal contraception / A. Balogh
Dátum:	1986
ISSN:	0236-5286
Megjegyzések:	Clinical effectiveness and side effects of a biphasic oral hormonal contraceptive preparation (levonorgestrel /LNG/ 10 X 0.05 mg+ + 11 X 0.125 mg, ethinyl oestradiol /EO/ 21 X 0.05 mg) were compared with the effect of a classical high fixed dose combination pill (LNG 21 X 0.25 mg, EO 21 X 0.05 mg). The biphasic pill was used by 121 women during 1844 cycles, while the fixed dose pill was used by 142 women during 1940 cycles. In the comparison with the life table method, termination of pill use for medical reasons and loss to follow up proved to be significantly different in favour of the biphasic pill.PIP:To collect data on clinical and laboratory effects of the oral contraceptives (OCs) marketed in Hungary, a prospective study was initiated in January 1983. Patient data were collected in regular intervals using standard statistical forms. During the first 2 years of the study, data were collected on 1256 women. A complete segment of the data was selected to be reported in this paper and included 1844 cycles of 121 women using a biphasic OC compared to 1940 cycles of 142 women using a classical formulation pill. The biphasic preparation was characterized by a very low levonorgestrel content with an average ethinyl estradiol dose; the reference preparation was a relatively high dose classical OC. No biologically significant difference was found between hormone and receptor levels. The basis of the comparison of the 2 preparations was the termination of OC use in the 2 groups as a function of time. The primary reasons for stopping administration of these preparations were unwanted pregnancy, medical reasons, critical age above 35, planned pregnancy, and other personal reasons. The difference between the 2 groups proved significant according to the life table method only in the category of medical reasons. Slightly more patients were lost to followup in the higher dose group. In the category of medical reasons, digestive tract complaints like nausea, vomiting, menstrual bleeding anomalies, too frequent bleeding-spotting, episodes of amenorrhea, weight gain, psychic disturbances, headache, breast tenderness, and swelling were prominent. These symptoms were most frequent in the first 3-4 months of OC use. The difference was due to the significantly higher rate of amenorrhea/hypomenorrhea, weight gain, and headache in the high dose monophasic pill group. The biphasic pill group was characterized by a slightly higher rate of gastrointestinal complaints and breast swelling. The overall difference favored the latter preparation. The biphasic OC did not cause a thrombotic change in homeostasis despite the fact that it was estrogen dominated. The basal levels of luteinizing hormone and follicle stimulating hormone were less affected in the biphasic OC users compared to the classical formulation OC users. Estradiol levels did not change significantly. The inhibition of ovulation was about the same with both treatment regimens.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Acta Medica Hungarica. - 43 : 2 (1986), p. 97-102. -
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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