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001-es BibID:	BIBFORM042546
Első szerző:	Putaala, Jukka
Cím:	Demographic and geographic vascular risk factor differences in European young adults with ischemic stroke :the 15 cities young stroke study / Jukka Putaala, Nilufer Yesilot, Ulrike Waje-Andreassen, Janne Pitkäniemi, Sofia Vassilopoulou, Katiuscia Nardi, Celine Odier, Gergely Hofgart, Stefan Engelter, Annika Burow, Laszlo Mihalka, Manja Kloss, Julia Ferrari, Robin Lemmens, Oguzhan Coban, Elena Haapaniemi, Noortje Maaijwee, Loes Rutten-Jacobs, Anna Bersano, Carlo Cereda, Pierluigi Baron, Linda Borellini, Caterina Valcarenghi, Lars Thomassen, Armin J. Grau, Frederick Palm, Christioan Urbanek, Rezzan Tuncay, Aysan Durukan-Tolvanen, Ewoud J. van Dijk, Frank-Erik de Leeuw, Vincent Thijs, Stefan Greisenegger, Konstantinos Vemmos, Christoph Lichy, Daniel Bereczki, Laszlo Csiba, Patrik Michel, Didier Leys, Konstantinos Spengos, Halvor Naess, Sara Zarko Bahar, Turgut Tatlisumak
Dátum:	2012
ISSN:	0039-2499
Megjegyzések:	Abstract - BACKGROUND AND PURPOSE: We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS: We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospective or consecutive young stroke registries involving 15 cities in 12 countries. Geographic regions were defined as northern (Finland, Norway), central (Austria, Belgium, France, Germany, Hungary, The Netherlands, Switzerland), and southern (Greece, Italy, Turkey) Europe. Hierarchical regression models were used for comparisons. RESULTS: In the study cohort (n=3944), the 3 most frequent risk factors were current smoking (48.7%), dyslipidemia (45.8%), and hypertension (35.9%). Compared with central (n=1868; median age, 43 years) and northern (n=1330; median age, 44 years) European patients, southern Europeans (n=746; median age, 41 years) were younger. No sex difference emerged between the regions, male:female ratio being 0.7 in those aged <34 years and reaching 1.7 in those aged 45 to 49 years. After accounting for confounders, no risk-factor differences emerged at the region level. Compared with females, males were older and they more frequently had dyslipidemia or coronary heart disease, or were smokers, irrespective of region. In both sexes, prevalence of family history of stroke, dyslipidemia, smoking, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial disease, and atrial fibrillation positively correlated with age across all regions. CONCLUSIONS: Primary preventive strategies for ischemic stroke in young adults-having high rate of modifiable risk factors-should be targeted according to sex and age at continental level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Stroke. - 43 : 10 (2012), p. 2624-30. -
További szerzők:	Yesilot Barlas, Nilufer Waje-Andreassen, Ulrike Pitkäniemi, Janne Vassilopoulou, Sofia Nardi, Katiuscia Odier, Celine Hofgárt Gergely (1984-) (neurológus) Engelter, Stefan Burow, Annika Mihálka László (1950-) (neurológus) Kloss, Manja Ferrari, Julia Lemmens, Robin Coban, Oguzhan Haapaniemi, Elena Maaijwee, Noortje Rutten-Jacobs, Loes Bersano, Anna Cereda, Carlo Baron, Pierluigi Borellini, Linda Valcarenghi, Caterina Thomassen, Lars Grau, Armin J. Palm, Frederick Urbanek, Christioan Tuncay, Rezzan Durukan-Tolvanen, Aysan Dijk, Ewoud J. van de Leeuw, Frank-Erik Thijs, Vincent Greisenegger, Stefan Vemmos, Konstantinos Lichy, Christoph Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Michel, Patrik Leys, Didier Spengos, Konstantinos Naess, Halvor Bahar, Sara Zarko Tatlisumak, Turgut
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