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001-es BibID:	BIBFORM042911
Első szerző:	Thirunavukkarasu, Mahesh
Cím:	Novel role of NADPH oxidase in ischemic myocardium : a study with Nox2 knockout mice / Thirunavukkarasu Mahesh, Adluri Ram Sudheer, Juhasz Bela, Samuel Samson Mathews, Zhan Lijun, Kaur Anupinder, Maulik Gautam, Sanchez Juan A., Hager Janet, Maulik Nilanjana
Dátum:	2012
ISSN:	1438-793X 1438-7948
Megjegyzések:	Several potential sources of reactive oxygen species (ROS) in cells exist. One source is NADPH oxidase, which is especially important for superoxide radical production. Nox2 is a primary regulatory subunit of NADPH oxidase. In the present study, we examined the role of ROS and NADPH oxidase in ischemic preconditioning (IP)-mediated cardioprotection by using Nox2(-/-) mice. Both wild-type (WT) and Nox2(-/-) mice were subjected to either 30 min of ischemia followed by 2 h of reperfusion (IR) or IP prior to 30 min ischemia and 2 h of reperfusion. Reduction in left ventricular developed pressure (60.1 versus 63 mmHg), dp/dt (max) (893 versus 1,027 mmHg/s), and aortic flow (0.9 versus 1.8 ml/min) was observed in Nox2(-/-)IPIR compared to WTIPIR along with increased infarct size (33% versus 22%) and apoptosis after 120 min of reperfusion. Differentially regulated genes were demonstrated by comparing gene expression in WTIPIR versus Nox2(-/-) IPIR hearts. Selected differentially regulated genes such as β-catenin, SRPK3, ERDR1, ACIN1, Syntaxin-8, and STC1 were validated by real-time PCR. Taken together, this is the first report identifying important, differentially expressed genes during ischemic preconditioning in Nox2(-/-) mice by using microarray analysis.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Functional & Integrative Genomics. - 12 : 3 (2012), p. 501-514. -
További szerzők:	Adluri, Ram Sudheer Juhász Béla (1978-) (kísérletes farmakológus) Samuel, Samson Mathews Zhan, Lijun Kaur, Anupinder Maulik, Gautam Sanchez, Juan A. Hager, Janet Maulik, Nilanjana
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