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001-es BibID:	BIBFORM043850
035-os BibID:	PMID:8813543
Első szerző:	Abdel Salam, Omar M. E.
Cím:	Effect of capsaicin and resiniferatoxin on gastrointestinal blood flow in rats / Omar M. E. Abdel Salam, János Szolcsányi, Róbert Pórszász, Gyula Mózsik
Dátum:	1996
ISSN:	0014-2999
Megjegyzések:	The effect of capsaicin and resiniferatoxin on gastrointestinal blood flow was studied in anaesthetized rats by laser Doppler flowmetry. Resiniferatoxin injected into the jugular vein (0.08-1.6 nmol/kg) produced a marked and dose-dependent increase in gastric blood flow, while the effect of capsaicin (0.33-19.6 nmol/kg) was transient, variable and accompanied by profound systemic blood pressure changes. After acute bilateral cervical vagotomy combined with sympathetic neurone blockade (guanethidine 16 mumol/kg) or alpha-adrenoceptor blockade (phentolamine 1.6 mumol/kg), the vasodilator response to injected resiniferatoxin was more pronounced, indicating that the resiniferatoxin-induced gastric vasodilatation is not due to reflexes via parasympathetic or sympathetic efferent fibres. Resiniferatoxin given i.v. (0.08-0.64 nmol/kg) evoked a similar increase in the blood flow of the jejunum. Capsaicin (0.33-33 microM) or resiniferatoxin (0.16-1.6 microM) applied topically to the serosal surface of the stomach or jejunum produced a pronounced and long-lasting increase in blood flow after vagotomy and guanethidine treatment. The blood flow and blood pressure responses to capsaicin and resiniferatoxin were absent in rats desensitized with systemic capsaicin pretreatment. These laser Doppler data provide the first evidence for the effect of resiniferatoxin on gastrointestinal microcirculation and indicate the advantages of this agent and technique to study the sensory-efferent function of capsaicin-sensitive fibres.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Pharmacology. - 305 : 1-3 (1996), p. 127-36. -
További szerzők:	Szolcsányi János (Pécs) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Mózsik Gyula
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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