Találati lista | Tudóstér

001-es BibID:	BIBFORM044036
Első szerző:	Besenyei Tímea (reumatológus, belgyógyász)
Cím:	Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models / Besenyei Timea, Kadar Andras, Tryniszewska Beata, Kurko Julia, Rauch Tibor A., Glant Tibor T., Mikecz Katalin, Szekanecz Zoltan
Dátum:	2012
ISSN:	1740-2522
Megjegyzések:	Rheumatoid arthritis (RA) is a polygenic autoimmune disease primarily affecting the synovial joints. Numerous animal models show similarities to RA in humans; some of them not only mimic the clinical phenotypes but also demonstrate the involvement of homologous genomic regions in RA. This paper compares corresponding non-MHC genomic regions identified in rodent and human genome-wide association studies (GWAS). To date, over 30 non-MHC RA-associated loci have been identified in humans, and over 100 arthritis-associated loci have been identified in rodent models of RA. The genomic regions associated with the disease are designated by the name(s) of the gene having the most frequent and consistent RA-associated SNPs or a function suggesting their involvement in inflammatory or autoimmune processes. Animal studies on rats and mice preferentially have used single sequence length polymorphism (SSLP) markers to identify disease-associated qualitative and quantitative trait loci (QTLs) in the genome of F2 hybrids of arthritis-susceptible and arthritis-resistant rodent strains. Mouse GWAS appear to be far ahead of rat studies, and significantly more mouse QTLs correspond to human RA risk alleles
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Rheumatoid arthritis polygenic autoimmune disease
Megjelenés:	Clinical And Development Immunology. - 2012 (2012), p. 1-14. -
További szerzők:	Kádár András (1977-) (belgyógyász) Tryniszewska Beáta Kurkó Júlia Emese (1979-) (reumatológus) Rauch Tibor A. Glant Tibor T. Mikecz Katalin Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: