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001-es BibID:	BIBFORM044310
Első szerző:	Korponay-Szabó Ilma (gyermekgyógyász)
Cím:	The human appendix : a composite substrate for anti-endomysium, anti-reticulin and anti-bowel antibody testing in coeliac disease / Ilma Rita Korponay-Szabó, Judit B. Kovács, Margit Lőrincz, Éva Török, Gyula Gorácz, Ferenc Csitáry
Dátum:	1997
Megjegyzések:	Primate tissues seem are important for the specificity of IgA type anti-endomysium (EmA),anti-reticulin (ARA) and anti-jejunum (JeA) antibody investigations in gluten-sensitive enteropathy(GSE). Substrate availability and costs for multiple testing are, however, frequent problems.METHODS: Sera of 300 non IgA-deficient GSE patients and 127 controls were tested on frozensections made from appendices surgically removed because of the suspicion of acuteappendicitis, but having normal histology. An indirect immunofluorescent method with IgA-stainingwas used. Conventional assays for EmA, ARA and JeA were carried out on monkey esophagus,human liver/kidney and jejunum respectively. Eighty sera were investigated also on humanumbilical cord tissue. RESULTS: A positive reaction on the appendix (App+) is composed of thestaining of the endomysium, reticulin network and tunica propria fibers, each corresponding to thestandard EmA, ARA and JeA pattern. 295/300 (98.3%) of the GSE patients and 0/127 of thecontrols were App+, without significant differences versus standard autoantibody reactions.Human umbilical cord positivity was observed in 50/54 GSE (92.6%) and in 2/26 (7.6%) controls(p<0.02 vs App+). Absorption studies resulted in fading of all components of App+, irrespective ofwhether esophagus, liver or jejunum had been used. CONCLUSIONS: Use of the human appendixtissue is a suitable and simple alternative to conventional EmA, JeA, ARA determinations. Allthree result in comparable specificity and sensitivity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban celiac disease
Megjelenés:	Medical Science Monitor. - 3 : 3 (1997), p. 295-289. -
További szerzők:	Kovács Judit B. Lőrincz Margit Török Éva Gorácz Gyula Csitáry Ferenc
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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