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001-es BibID:	BIBFORM046274
Első szerző:	Gáspár Rezső (biofizikus)
Cím:	[Béta]-scorpion toxin 2 from Centruroides noxius blocks voltage-gated K+ channels in human lymphocytes / Gaspar R., Bene L., Damjanovich S., Munoz-Garay C., Calderon-Aranda E. S., Possani L. D.
Dátum:	1995
ISSN:	0006-291X
Megjegyzések:	Using the patch-clamp technique, we determined that beta-scorpion toxin 2 from Centruroides noxius Hoffmann decreased whole-cell n-type K+ currents in human peripheral blood lymphocytes, with a half blocking concentration of approx. 5 microM. Toxin-2-accelerated inactivation, however, did not influence the kinetics of activation of the K+ conductance. The percentage increase in K+ channel inactivation rate and the degree of drug-induced block was independent of membrane potential. K+ channel block by Toxin 2 was instantaneous, not removable by washing with drug free extracellular solution. However, 10 mg/ml BSA in the bath lifted the toxin-induced block almost instantaneously and completely. Flow cytometric membrane potential measurements with the oxonol dye showed that Toxin 2 depolarizes human lymphocytes in concert with its K+ channel blocking effect.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical And Biophysical Research Communications. - 213 : 2 (1995), p. 419-423. -
További szerzők:	Bene László (1963-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Munoz-Garay, Carlos Calderon-Aranda, Emma S. Possani, Lourival Domingos
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