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001-es BibID:	BIBFORM046306
Első szerző:	Varga Zoltán (biofizikus, szakfordító)
Cím:	The Effect of Juglone on the Membrane Potential and Whole-Cell K+Currents of Human Lymphocytes / Varga Z., Bene L., Pieri C., Damjanovich S., Gaspar R.
Dátum:	1996
ISSN:	0006-291X
Megjegyzések:	Using flow cytometric membrane potential measurements with the oxonol dye, we determined that 5.7-57 microM juglone depolarizes human lymphocytes in a dose dependent manner. The depolarizing effect of juglone was verified by patch-clamp. Juglone decreased whole-cell n-type K+ currents in human peripheral blood lymphocytes and accelerated inactivation; however, it did not influence the kinetics of activation of the K+ conductance. The percentage increase in K+ channel inactivation rate and the degree of drug induced block was independent of membrane potential, K+ channel block by juglone fully developed within 4 minutes and was not removable by washing with drug free extracellular solution. Blocking of n-type K+ channels by juglone is in concert with its depolarizing effect on human lymphocytes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical And Biophysical Research Communications. - 218 : 3 (1996), p. 828-832. -
További szerzők:	Bene László (1963-) (biofizikus) Pieri, Carlo Damjanovich Sándor (1936-2017) (biofizikus) Gáspár Rezső (1944-) (biofizikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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