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001-es BibID:	BIBFORM046437
Első szerző:	Literáti-Nagy Zsuzsanna
Cím:	A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics / Zsuzsanna Literati-Nagy, Kálmán Tory, Botond Literáti-Nagy, Attila Kolonics, László Vígh Jr., László Vígh, József Mandl, Zoltán Szilvássy
Dátum:	2012
ISSN:	1219-4956 1532-2807
Megjegyzések:	Atypical antipsychotic drugs (AAPD) are widelyused to treat severe psychiatric disorders, have well documentedmetabolic side effects such as disturbances in glucosemetabolism, insulin resistance and weight gain. It hasbeen shown that BGP-15, a hydroxylamine derivative withinsulin sensitizing activity can prevent AAPD provoked fataccumulation in adipocyte cultures, and insulin resistance inanimal experiments and in healthy volunteers. The aim ofthis study was to compare the preventive effect of BGP-15with conventional oral antidiabetics on metabolic sideeffects of AAPDs. We found that BGP-15 that does notbelong to either conventional insulin sensitizers or oralantidiabetics, is able to counteract insulin resistance andweight gain provoked by antipsychotic agents in rats whilerosiglitazone and metformin were not effective in the applieddoses. Our results confirm that BGP-15 is a promisingnew drug candidate to control the metabolic side effects ofatypical antipsychotics. Data indicate that this rat model issuitable to analyze the metabolic side effects of AAPDs andthe protective mechanism of BGP-15.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Atypical antipsychotic drugs Side effects BGP-15 Hydroxylamine derivative Insulin resistance Weight gain Hyperinsulinaemic euglycaemic glucose clamp
Megjelenés:	Pathology & Oncology Research. - 18 : 4 (2012), p. 1071-1076. -
További szerzők:	Tory Kálmán Literáti-Nagy Botond Kolonics Attila Vígh László Jr. Vígh László (orvos Szeged) Mandl József Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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