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001-es BibID:	BIBFORM046775
035-os BibID:	PMID:15256976
Első szerző:	Lakatos Péter (Semmelweis Egyetem)
Cím:	Insulin-like growth factor I gene microsatellite repeat, collagen type Ialpha1 gene Sp1 polymorphism, and bone disease in primary biliary cirrhosis / Peter Laszlo Lakatos, Eva Bajnok, Istvan Tornai, Aniko Folhoffer, Andrea Horvath, Peter Lakatos, Andrzej Habior, Ferenc Szalay
Dátum:	2004
ISSN:	0954-691X
Megjegyzések:	BACKGROUND:Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis. Insulin-like growth factor I (IGF-I) gene microsatellite repeat polymorphism was found to be associated with osteoporosis in some studies, and collagen-Ialpha1 (COLIA1) Sp1 s allele was associated with lower bone mineral density in primary biliary cirrhosis. IGF-I treatment restored osteopenia and reduced fibrogenesis in experimental cirrhosis. We investigated IGF-I and COLIA1 gene polymorphisms and bone mineral density in Hungarian primary biliary cirrhosis patients.PATIENTS AND METHODS:Seventy female patients with primary biliary cirrhosis were enrolled (mean age 57.6 years, range 37-76 years; all anti-mitochondrial antibody M2-positive; stage II-IV). One hundred and thirty-nine age-matched female subjects served as controls (mean age 55.9 years, range 43-72 years). COLIA1 and IGF-I polymorphisms were determined by polymerase chain reaction. Bone mineral density was measured by dual-energy X-ray absorptiometry in the lumbar spine and femoral neck.RESULTS:The IGF-I was not different between primary biliary cirrhosis patients and controls. The genotype frequency of COLIA1 polymorphism was also not different between primary biliary cirrhosis patients and controls. However, the s allele was significantly less frequent in patients with primary biliary cirrhosis. Osteoporosis was detected in 22 patients. The IGF-I 192/192 genotype was associated with higher femoral-neck z-scores compared with other genotypes.CONCLUSION:In contrast to previous studies, the s allele was less frequent in patients with primary biliary cirrhosis, and its presence was not associated with bone mineral density. Since IGF-I polymorphism was associated with bone mineral density, it may be hypothesised that not COLIA1 but IGF-I together with other genetic and environmental factors may be involved in the complex regulation of bone mineral density in primary biliary cirrhosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Gastroenterology & Hepatology. - 16 : 8 (2004), p. 753-759. -
További szerzők:	Bajnok Éva Tornai István (1954-) (belgyógyász, gasztroenterológus) Folhoffer Anikó Horváth Andrea Lakatos Péter (belgyógyász) Habior, Andrzej Szalay Ferenc (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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