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001-es BibID:	BIBFORM046811
Első szerző:	Benkő Ilona (orvos, farmakológus)
Cím:	Comparison of the toxicity of fluconazole and other azole antifungal drugs to murine and human granulocyte-macrophage progenitor cells in vitro / Benko I., Hernádi F., Megyeri A., Kiss A., Somogyi G., Tegyey Z., Kraicsovits F., Kovács P.
Dátum:	1999
ISSN:	0305-7453
Megjegyzések:	We studied the inhibitory effects on colony formation by granulocyte-macrophage colony forming units (cfu-gm) of eight azole antifungal agents in vitro. All agents, except fluconazole, inhibited colony formation dose-dependently with 50% inhibitory concentrations (IC50) in the range of 0.78-49 micromol/L in cultures of murine and human bone marrow. For human cells, the IC50 values were 0.553 mg/L for itraconazole, 1.24 mg/L for saperconazole, 2.58 mg/L for clotrimazole, 5.33 mg/L for miconazole, 6.17 mg/L for econazole, 6.27 mg/L for ketoconazole and 8.38 mg/L for oxiconazole. The IC50 of itraconazole for human cfu-gm in vitro was similar to the plasma level of this drug recommended for systemic antifungal therapy (>0.5 mg/L) thus indicating the potential clinical relevance of our data. The IC50 of ketoconazole for human cfu-gm in vitro may be exceeded by plasma levels produced in vivo by high (> or =400 mg) doses, whereas fluconazole failed to reduce colony formation by 50% even at 100 mg/L, a concentration not reached in vivo even after extremely high doses (2000 mg/day). To most of the drugs studied, murine progenitor cells seemed to be less sensitive than the human ones. There was, however, a close correlation between the murine and human log IC50 values of the drugs (r2 = 0.964, P< 0.001), suggesting that cultures of murine bone marrow may be suitable to predict the in-vitro toxicity of azole antifungals to human cfu-gm.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban fluconazole antifungal drugs granulocyte macrophage in vitro
Megjelenés:	Journal of Antimicrobial Chemotherapy. - 43 : 5 (1999), p. 675-681. -
További szerzők:	Hernádi Ferenc (1929-) (farmakológus) Megyeri Attila (1968-) (orvos) Kiss Attila (1942-) (belgyógyász, haematológus) Somogyi G. Tegyey Z. Kraicsovits F. Kovács Péter (1939-) (farmakológus)
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