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001-es BibID:	BIBFORM047530
Első szerző:	Kappelmayer János (laboratóriumi szakorvos)
Cím:	Prediction of therapy response and prognosis in leukemias by flow cytometric MDR assays / János Kappelmayer, Zsuzsa Hevessy, András Apjok, Katalin Tauberné Jakab
Dátum:	2012
Megjegyzések:	Multidrug resistance (MDR) is an unwanted phenomenon, that may cause therapy failure in several neoplasms includinghematological malignancies. The purpose of any type of laboratory MDR assay is to reliably identify such patients and to provideuseful data to clinicians with a relatively short turnaround time. MDR can be multicausal and several previous data identified agroup of transmembrane proteins - the ATP-binding casette (ABC) proteins - that may be involved in MDR in varioushematological malignancies. The prototype of these proteins is the P-glycoprotein (Pgp, MDR1, ABCB1) that is a seven-membranespanning transmembrane protein capable of extruding several cytotoxic drugs that are of key importance in the treatmentof hematological disorders. Similarly other ABC proteins ? Multidrug resistance associated protein 1 (ABCC1) and breastcancer resistance protein (ABCG2) are both capable of pumping out cytotoxic drugs. Here, we present flow cytometric methodsto identify MDR proteins by antigen and activity assays. The advantage of flow technology is the short turnaround time and itsrelative easiness compared to nucleic acid based technologies. However, for the activity assays, it should be noted, that thesefunctional tests require live cells, thus adequate results can only be provided if the specimen transport can be completed within6 hours of sample collection. Identification of MDR proteins provides prognostic information and may modulate therapy, thussignifies a clinically useful information in the evaluation of patients with leukemias.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban flow cytometry leukemia drug-resistance
Megjelenés:	The Electronic Journal Of The International Federation Of Clinical Chemistry And Laboratory Medicine. - 23 : 4 (2012), p. 117-123. -
További szerzők:	Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos) Apjok András Tauberné Jakab Katalin (Szeged)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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