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001-es BibID:	BIBFORM047940
Első szerző:	Placidi, Matteo P.
Cím:	Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives : Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes / Matteo P. Placidi, Mauro Botta, Ferenc K. Kálmán, Gisela E. Hagberg, Zsolt Baranyai, Andreas Krenzer, Alexandria K. Rogerson, Imre Tóth, Nikos K. Logothetis, Goran Angelovski
Dátum:	2013
ISSN:	0947-6539
Megjegyzések:	A series of low molecular weight lanthanide complexes were developed that have high 1H longitudinal relaxivities (r1) and the potential to be used as dual frequency 1H and 19FMRprobes. Their behavior was investigated in more detail through relaxometry, pH-potentiometry, luminescence, andmultinuclear NMR spectroscopy. Fitting of the 1H NMRD and 17O NMR profiles demonstrated a very short water residence lifetime (<10 ns) and an appreciable second sphere effect. At lower field strengths (20 MHz), two of the complexes displayed a peak in r1 (21.7 and 16.3 mm 1 s 1) caused by anagglomeration, that can be disrupted through the addition of phosphate anions. NMR spectroscopy revealed that at least two species are present in solution interconverting through an intramolecular binding process. Two complexes provided a suitable signal in 19F NMR spectroscopy and through the selection of optimized imaging parameters,phantom images were obtained in a MRI scanner at concentrations as low as 1 mm. The developed probescould be visualized through both 1H and 19F MRI, showing their capability to function as dual frequency MRI contrastagents.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban fluorine gadolinium imaging agents NMR spectroscopy relaxivity
Megjelenés:	Chemistry-A European Journal. - 19 : 35 (2013), p. 11644-11660. -
További szerzők:	Botta, Mauro Kálmán Ferenc K. (1978-) (vegyész) Hagberg, Gisela E. Baranyai Zsolt (1977-) (vegyész) Krenzer, Andreas Rogerson, Alexandria K. Tóth Imre (1950-) (vegyész) Logothetis, Nikos K. Angelovski, Goran
Pályázati támogatás:	PD-83253 OTKA K-84291 OTKA TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP TÁMOP-4.2.2A-11/1/KONV-2012-0043 TÁMOP COST TD1004 "Theranostics Imaging and Therapy: An Action To Develop Novel Nanosized Systems For Imaging-Guided Drug Delivery" Egyéb COST CM1006 "EUFEN: European F-Element Network" Egyéb
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