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001-es BibID:	BIBFORM048492
Első szerző:	Szállási Árpád (pathológus)
Cím:	Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog / Arpad Szallasi, Ferenc Joo, Peter M. Blumberg
Dátum:	1989
ISSN:	0006-8993
Megjegyzések:	We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the maximal tolerated dose of RTX. Desensitization to neurogenic inflammation began to diminish by 7 days, whereas desensitization to pain and to induction of hypothermia persisted for several weeks. Interestingly, a partial hypothermic response returned within 24 h if challenge was with RTX at 500-fold its ED50 for control animals; the animals, moreover, maintained their ability to thermoregulate in a hot environment. The time course of the morphological changes--ultrastructure and calcium staining--of dorsal root ganglion neurons was examined in parallel. The ultrastructural changes were evident by 4 h and persisted for the duration of the experiments. Limited calcium staining was visible at 12 and 24 h after treatment but then diminished. In comparison with capsaicin treatment, RTX caused more long-lasting desensitization as well as a distinct spectrum of response.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Dorsal root ganglion Resiniferatoxin Capsaicin analog Desensitization
Megjelenés:	Brain research. - 503 : 1 (1989), p. 68-72. -
További szerzők:	Joó Ferenc (1949-) (vegyész) Blumberg, Peter M.
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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