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001-es BibID:	BIBFORM048677
035-os BibID:	PMID:23416893
Első szerző:	Virág László (biokémikus, sejtbiológus, farmakológus)
Cím:	Poly(ADP-ribose) signaling in cell death / László Virág, Agnieszka Robaszkiewicz, Jose Manuel Rodriguez-Vargas, Francisco Javier Oliver
Dátum:	2013
ISSN:	0098-2997 1872-9452
Megjegyzések:	Poly(ADP-ribosyl)ation (PARylation) is a reversible protein modification carried out by the concerted actions of poly(ADP-ribose) polymerase (PARP) enzymes and poly(ADP-ribose) (PAR) decomposing enzymes such as PAR glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3). Reversible PARylation is a pleiotropic regulator of various cellular functions but uncontrolled PARP activation may also lead to cell death. The cellular demise pathway mediated by PARylation in oxidatively stressed cells has been described almost thirty years ago. However, the underlying molecular mechanisms have only begun to emerge relatively recently. PARylation has been implicated in necroptosis, autophagic cell death but its role in extrinsic and intrinsic apoptosis appears to be less predominant and depends largely on the cellular model used. Currently, three major pathways have been made responsible for PARP-mediated necroptotic cell death: (1) compromised cellular energetics mainly due to depletion of NAD, the substrate of PARPs; (2) PAR mediated translocation of apoptosis inducing factor (AIF) from mitochondria to nucleus (parthanatos) and (3) a mostly elusive crosstalk between PARylation and cell death/survival kinases and phosphatases. Here we review how these PARP-mediated necroptotic pathways are intertwined, how PARylation may contribute to extrinsic and intrinsic apoptosis and discuss recent developments on the role of PARylation in autophagy and autophagic cell death.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Apoptosis Autophagy Cell death Necroptosis Necrosis Oxidative stress Poly(ADP-ribose) glycohydrolase Poly(ADP-ribose) polymerase Molekuláris Medicina
Megjelenés:	Molecular Aspects of Medicine. - 34 : 6 (2013), p. 1153-1167. -
További szerzők:	Robaszkiewicz, Agnieszka (1983-) (biokémikus) Rodriguez-Vargas, Jose Manuel Oliver, Francisco Javier
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0025 TÁMOP TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Oxidatív stressz és ADP-riboziláció kapcsolatának vizsgálata
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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