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001-es BibID:	BIBFORM049047
035-os BibID:	(cikkazonosító)012002 (WOS)000329184000002 (Scopus)84893779805
Első szerző:	Szalóki Melinda (vegyész)
Cím:	Binding of leachable components of polymethyl methacrylate (PMMA) and peptide on modified SPR chip / M. Szalóki, G. Vitályos, J. Hársfalvi, Cs. Hegedűs
Dátum:	2013
ISSN:	1757-8981 1757-899X
Megjegyzések:	Abstract. Many types of polymers are often used in dentistry, which may cause allergic reaction, mainly methyl methacrylate allergy due to the leachable, degradable components of polymerized dental products. The aim of this study was to investigate the interaction between the leachable components of PMMA and peptides by Fourier-transform Surface Plasmon Resonance (FT SPR). In our previous work binding of oligopeptides (Ph.D.-7 and Ph.D.-12 Peptide Library Kit) was investigated to PMMA surface by phage display technique. It was found that oligopeptides bounded specifically to PMMA surface. The most common amino acids were leucine and proline inside the amino acids sequences of DNA of phages. The binding of haptens, as formaldehyde and methacrylic acid, to frequent amino acids was to investigate on the modified gold SPR chip. Self assembled monolayer (SAM) modified the surface of gold chip and ensured the specific binding between the haptens and amino acids. It was found that amino acids bounded to modified SPR gold and the haptens bounded to amino acids by creating multilayer on the chip surface. By the application of phage display and SPR modern bioanalytical methods the interaction between allergens and peptides can be investigated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok konferenciacikk folyóiratcikk phage display FT-SPR PMMA dental allergens Doktori iskola
Megjelenés:	IOP Conference Series. Materials Science and Engineering. - 47 (2013), p. 1-6. -
További szerzők:	Vitályos Géza (1970-) (egyetemi tanársegéd, fogszakorvos) Hársfalvi Jolán (1949-) (klinikai biokémikus) Hegedűs Csaba (1953-) (fogszakorvos)
Pályázati támogatás:	TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP Fogorvostudományi Doktori Iskola
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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