Találati lista | Tudóstér

001-es BibID:	BIBFORM049718
Első szerző:	Gyires Klára
Cím:	Gastric mucosal protection and central nervous system / Klara Gyires, József Németh, Zoltán S. Zádori
Dátum:	2013
ISSN:	1381-6128
Megjegyzések:	Several human and experimental data suggest the particular importance of gastric protective processes in maintaining mucosalintegrity. Both peripheral and central mechanisms are involved in this process. In the periphery, pre-epithelial mucus-bicarbonate layer,mucus, phospholipids, trefoil peptides, prostaglandins, heat shock proteins, sensory neuropeptides, nitric oxide, and hydrogen sulfide maymediate mucosal protection. In the central nervous system hypothalamus and dorsal vagal complex (DVC) have particular important rolein the regulation of centrally-induced gastroprotection. Stimulation of paraventricular nuclei either aggravates or inhibits the mucosal injurydepending on the ulcer model. Vagal nerve also has a dual role, its activation can induce mucosal injury (by high dose of thyrotropin-releasing hormone (TRH), electrical stimulation), however, integrity of vagal nerve is necessary for gastroprotection induced eitherperipherally (by PGE2, prostacyclin, adaptive cytoprotection), or centrally (e.g. by neuropeptides). The centrally induced gastroprotectionis likely to be vagal dependent, though vagal independent pathways have also been shown. Endomorphin-1 and endomorphin-2, selective?-opioid receptor ligands, proved to be highly potent and effective gastroprotective agents in ethanol ulcer model (0.03-3 pmol intracerebroventricularly).Inhibition of the degradation of endomorphins by diprotin A resulted in gastroprotective effect, indicating the potentialrole of these endogenous opioids in the regulation of gastric mucosal integrity. Endomorphin-2 injected intracerebroventricularly restoredthe reduced levels of CGRP and somatostatin in gastric mucosa induced by ethanol. In conclusion, neuropeptides expressed in dorsal vagalcomplex and hypothalamus may have a regulatory role in maintaining gastric mucosal integrity by stimulating the formation of mucosalprotective compounds.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Gastric Mucosal Protection Peripheral Central Mechanism Neuropeptides Endomorphins
Megjelenés:	Current Pharmaceutical Design. - 19 (2013), p. 34-39. -
További szerzők:	Németh József (1954-) (vegyész, analitikus) Zádori Zoltán S. (Farmakológia, gasztrointesztinális farmakológia)
Pályázati támogatás:	75965 OTKA TÁMOP-4.2.1/B-09/1/KMR-2010 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: