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001-es BibID:	BIBFORM050448
Első szerző:	Sántha Péter
Cím:	The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons / P. Sántha, Á. Jenes, Cs. Somogyi, I. Nagy
Dátum:	2010
ISSN:	0231-424X 1588-2683
Megjegyzések:	The activity of the transient receptor potential vanilloid type 1 ion channel (TRPV1) that is expressed by the great majority of polymodal nociceptors is pivotal for the development of inflammatory heat hyperalgesia. The responsiveness of TRPV1 is regulated by a series of intracellular signalling molecules including the cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA); increased or decreased PKA activity results in TRPV1 sensitisation or desensitisation, respectively. Activation of the cannabinoid 1 (CB1) receptor that is expressed by the majority of the TRPV1-expressing primary sensory neurons reduces PKA activity. Therefore, here we studied whether activation of the CB1 receptor resulted in reduced TRPV1-mediated responses in cultured rat primary sensory neurons. We found that TRPV1-mediated whole-cell currents were significantly reduced respectively, by 50% and 25% by 10 nM and 30 nM of the endogenous CB1 receptor agonist, anandamide. The PKA inhibitor, H89 also had a significant inhibitory effect on TRPV1-mediated currents (~70%). These findings suggest that activation of the CB1 receptor can reduce the activity of TRPV1 in primary sensory neurons, and that this inhibitory effect could be mediated through the reduction of PKA-mediated phosphorylation of TRPV1.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban anandamide capsaicin heat hyperalgesia inflammation TRPV1 nociception vanilloid PKA
Megjelenés:	Acta Physiologica Hungarica. - 97 : 2 (2010), p. 149-158. -
További szerzők:	Jenes Ágnes (1980-) (élettanász) Somogyi Csilla (1983-) (biológus, angol-magyar szakfordító) Nagy Istvan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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