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001-es BibID:	BIBFORM051035
Első szerző:	Vad Szilvia (nőgyógyász)
Cím:	Antiphospholipid antibodies in young women with and without oral contraceptive use / Vad S., Lakos G., Kiss E., Sipka S., Csorba R., Póka R.
Dátum:	2002
Megjegyzések:	Introduction: Antiphospholipid antibodies are associated with arterial and venosus thrombosis and recurrent pregnancy loss. High titre of antiphospholipid antibodies has been shown to associated with increased risk for future ischemic stroke, venosus thrombosis and myocardial infarction in men. In this study, we analysed the occurence of antiphospholipid antibodies among asymptomatic young women with and without oral contraceptive use. Patients and methods: We performed a cross-sectional study among 223 apparently healthy, non-pregnant, young women to survey the occurence of antiphospholipid antibodies among users and non- users of OC. Serum levels of IgG, IgA and IgM isotypes of anti-b2-glycoprotein I and anticardiolipin antibodies were measured by validated ELISA methods. Means of continuous variables in the two study groups were compared my c2- test. Differences in the frequency of abnormal results were expressed by odds- ratio and 95% confidence intervals were generated for the assessment of statistical significance. Results: There were no statistically significant differences between pill- users and non-users in age, total length of past gestation, frequency of miscarriage or infertility, family history of deep vein thrombosis and the day of menstrual cycle on which blood was drawn. Combining all types of antiphospholipid antibodies, pill- users had an elevated antibody titre more than twice as frequently than non-users (OR=2.3, 95% CI 1.1-5.1). The hogher frequency of elevated antibody titre was related most commonly to IgG type anti-b2-glycoprotein I antibodies. Conclusion: Oral contraceptive use increases the risk of elevated antiphospholipid antibody levels among asymptomatic young women. Further studies are needed to assess longitudinal changes in antiphospholipid antibody levels during oral contraception.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt antiphospholipid antibody contraception women
Megjelenés:	Ceska Gynekologia. - 67 : Suppl. 2 (2002), p. 34. -
További szerzők:	Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Kiss Emese (1960-) (belgyógyász, immunológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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