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001-es BibID:	BIBFORM051286
035-os BibID:	(Scopus)84886654223 (WoS)000328304800009
Első szerző:	Ferrante, Christopher J.
Cím:	Analysis of osmotic stress induced Ca2+ spark termination in mammalian skeletal muscle / Christopher Ferrante, Henrietta Szappanos, László Csernoch, Noah Weisleder
Dátum:	2013
Megjegyzések:	Ca2+ sparks represent synchronous opening of the ryanodine receptor (RyR) Ca2+ release channels located at the sarcoplasmic reticulum (SR) membrane. Whereas a quantal nature of Ca2+ sparks has been defined in cardiac muscle, the regulation of Ca2+ sparks in skeletal muscle has not been well-studied. Osmotic-stress applied to an intact skeletal muscle fiber can produce brief Ca2+ sparks and prolonged Ca2+ burst events. Here, we show that termination of Ca2+ bursts occurs in a step wise and quantal manner. Ca2+ burst events display kinetic features that are consistent with the involvement of both stochastic attrition and coordinated closure of RyR channels in the termination of SR Ca2+ release. Elemental unitary transition steps could be defined with a mean Delta F/F-0 of similar to 0.28, corresponding to the gating of 1-2 RyR channels. Moreover, the amplitude of the elemental transition steps declines at the later stage of the burst event. In tandem Ca2+ burst events where two Ca2+ bursts occur at the same position within a fiber in rapid succession, the trailing event is consistently of lower amplitude than the initial event. These two complementary results suggest that SR Ca2+ release may be associated with local depletion of SR Ca2+ stores in mammalian skeletal muscle.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Indian Journal of Biochemistry & Biophysics. - 50 (2013), p. 411-418. -
További szerzők:	Szappanos Henrietta (1976-) (biológus, élettanász) Csernoch László (1961-) (élettanász) Weisleder, Noah
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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