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001-es BibID:	BIBFORM051574
035-os BibID:	PMID:17352244
Első szerző:	Nádasi Edit
Cím:	Prognostic factors in Hungarian breast cancer patients / Edit Nádasi, Béla Anga, János Sándor, Judit Megyesi, Dezső Kelemen, Marcella Mottolese, Pier Giorgio Natali, Géza Hegedűs, István Arany, István Ember
Dátum:	2007
Megjegyzések:	Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients. MATERIALS AND METHODS: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK). RESULTS: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR). CONCLUSION: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban breast cancer immunohistochemistry prognostic factors activated extracellular signal-regulated kinase odds ratio
Megjelenés:	Anticancer Research. - 27 : 1A (2007), p. 279-282. -
További szerzők:	Anga Béla Sándor János (1966-) (orvos-epidemiológus) Megyesi Judit Kelemen Dezső Mottolese, Marcella Natali, Pier Giorgio Hegedűs Géza Arany István Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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