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001-es BibID:	BIBFORM054369
Első szerző:	Asijee, Guus M.
Cím:	Platelet vinculin : a substrate of activated factor XIII / Guus M. Asijee, Lászlo Muszbek, János Kappelmayer, János Polgár, Andrea Horváth, Auguste Sturk
Dátum:	1988
ISSN:	0167-4838
Megjegyzések:	In addition to plasma, Factor XIII of blood coagulation (FXIII) is also present in the cytosol of platelets, monocytes and macrophages. However, its intracellular function has not yet been revealed. Activated Factor XIII (FXIIIa) is a transglutaminase (protein-glutamine: amine γ-glutamyltransferase, EC 2.3.2.13) of highly restricted substrate specificity with only a few known protein substrates. In this report, we showed that FXIIIa can link dansylcadaverine, radiolabelled histamine and putrescine to vinculin. Quantitative determinations revealed that in the vinculin molecule a single glutamine residue can serve as acyl donor for the incorporation of small-molecular-weight amines. Vinculin could not be crosslinked to another vinculin molecule. It could be covalently bound, however, to fibrinogen, which indicates that the acyl donor glutamine residue can be engaged in an ?-(γ-glutamyl)lysyl crosslink formation. Since it has been shown that platelet actin and myosin, two main components of cytoskeleton, are also substrates for FXIIIa, and that vinculin is associated to the cytoskeleton during platelet activation, the involvement of FXIII in the stabilization of cytoskeleton at certain phases of cellular function is a likely possibility.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Vinculin Cytoskeleton Factor XIII Transglutaminase Protein-glutamin γ-glutamyltransferase
Megjelenés:	Biochimica et Biophysica Acta (BBA). Protein Structure and Molecular Enzymology. - 954 (1988), p. 303-308. -
További szerzők:	Muszbek László (1942-) (haematológus, kutató orvos) Kappelmayer János (1960-) (laboratóriumi szakorvos) Polgár János Horváth Andrea Sturk, Auguste
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