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001-es BibID:	BIBFORM056299
Első szerző:	Gór Balázs
Cím:	A Novel High Accuracy Algorithm for Reference Assembly in Colour Space / Balazs Gor, Anett Balla, Edit Tukacs, Istvan Nagy, Zsolt Torok
Dátum:	2012
Megjegyzések:	Although numerous algorithms exist for genome alignment using Next Generation Sequencingtags, assembly of colour coded reads remains a challenge. We present a novel pairwisesequence aligner algorithm derived from Smith-Waterman method. Original feature of thealgorithm is that it translates the reference sequence into colour code and performs the alignmentin colour space. While operating on this base it can prevent most read error-derived assemblyerrors. Based on dynamic programming it gives the optimal alignment in colour space. Further,validation on empirical dataset with capillary sequencing proved high mapping accuracy. We canalso conclude that the novel algorithm provides performance comparable with the currentlyavailable solutions. The algorithm can be implemented into any reference assembly softwarethereby improving mapping accuracy while maintaining high speed mapping.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Sequencing Bioinformatics Assembly Smith-Waterman Reference Assembly Colour Space Code Algorithm Next Generation Sequencing
Megjelenés:	International Journal of Biometrics and Bioinformatics (IJBB). - 6 : 4 (2012), p. 92-104.
További szerzők:	Balla Anett Tukacs Edit Nagy István Török Zsolt (1975-) (orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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