Találati lista | Tudóstér

001-es BibID:	BIBFORM056692
Első szerző:	Pavlidis, Polychronis
Cím:	Diagnostic and clinical significance of Crohn's disease-specific anti-MZGP2 pancreatic antibodies by a novel ELISA / Polychronis Pavlidis, Zakera Shums, Andreas L. Koutsoumpas, Jay Milo, Maria Papp, Takeji Uemurea, Peter Lakatos, Daniel S. Smyk, Dimitrios P. Bogdanos, Alastair Forbes, Gary L. Norman
Dátum:	2015
ISSN:	0009-8981
Megjegyzések:	BACKGROUND:We developed a new IgA and IgG anti-MZGP2 antibody ELISAs based on recombinant isoform-4 of human zymogen granule protein-2 (GP2), which is the major autoantigen of Crohn's disease (CrD)-specific pancreatic autoantibodies and assessed their clinical relevance in the largest inflammatory bowel disease (IBD) cohort tested to date.METHODS:832 sera were studied, including 617 consecutive IBD patients from 323 CrD and 294 ulcerative colitis (UC) follow-up in a tertiary centre, and 112 pathological and 103 normal controls.RESULTS:Sensitivity of IgA anti-MZGP2 for CrD in the IBD population was 15% and specificity was 98% (95, 99), while the sensitivity and specificity of IgG anti-MZGP2 were 27% and 97%. IgA and IgG anti-MZGP2 combined testing led to a sensitivity of 31% and a specificity of 96%. Positivity for either ASCA (IgA or IgG) or anti-MZGP2 (IgA or IgG) showed a sensitivity of 75% (70, 80) and a specificity of 84% (79, 89). IgA anti-MZGP2 antibodies were more prevalent in CrD patients with early disease onset (p=0.011). Also, anti-MZGP2 positive patients more frequently had extensive disease with ileal involvement. Patients with longer disease duration were more likely to have IgG anti-MZGP2 antibodies.CONCLUSIONS:Our novel ELISA confirms the high specificity of anti-MZGP2 antibodies for CrD and their association with disease severity phenotypes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Autoantibody Bowel disease Marker Sensitivity Specificity
Megjelenés:	Clinica Chimica Acta. - 441 (2015), p. 176-181. -
További szerzők:	Shums, Zakera Koutsoumpas, Andreas L. Milo, Jay Papp Mária (1975-) (belgyógyász, gasztroenterológus) Uemurea, Takeji Lakatos Péter Smyk, Daniel S. Bogdanos, Dimitrios P. Forbes, Alastair Norman, Gary L.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: