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001-es BibID:	BIBFORM057403
Első szerző:	Szentandrássy Norbert (élettanász)
Cím:	Contribution of ion currents to beat-to-beat variability of action potential duration in canine ventricular myocytes / Norbert Szentandrássy, Kornél Kistamás, Bence Hegyi, Balázs Horváth, Ferenc Ruzsnavszky, Krisztina Váczi, János Magyar, Tamás Bányász, András Varró, Péter P. Nánási
Dátum:	2015
ISSN:	0031-6768
Megjegyzések:	Although beat-to-beat variability (short-term variability, SV) of action potential duration (APD) is considered as a predictor of imminent cardiac arrhythmias, the underlying mechanisms are still not clear. In the present study, therefore, we aimed to determine the role of the major cardiac ion currents, APD, stimulation frequency, and changes in the intracellular Ca2+ concentration ([Ca2+]i) on the magnitude of SV. Action potentials were recorded from isolated canine ventricular cardiomyocytes using conventional microelectrode techniques. SV was an exponential function of APD, when APD was modified by current injections. Drug effects were characterized as relative SV changes by comparing the drug-induced changes in SV to those in APD according to the exponential function obtained with current pulses. Relative SV was increased by dofetilide, HMR 1556, nisoldipine, and veratridine, while it was reduced by BAY K8644, tetrodotoxin, lidocaine, and isoproterenol. Relative SV was also increased by increasing the stimulation frequency and [Ca2+]i. In summary, relative SV is decreased by ion currents involved in the negative feedback regulation of APD (I Ca, I Ks, and I Kr), while it is increased by I Na and I to. We conclude that drug-induced effects on SV should be evaluated in relation with the concomitant changes in APD. Since relative SV was decreased by ion currents playing critical role in the negative feedback regulation of APD, blockade of these currents, or the beta-adrenergic pathway, may carry also some additional proarrhythmic risk in addition to their well-known antiarrhythmic action.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Short-term variability Action potential duration Ion currents Canine myocytes Action potential configuration Doktori iskola
Megjelenés:	Pflügers Archiv. - 467 : 7 (2015), p. 1431-1443. -
További szerzők:	Kistamás Kornél (1986-) (biológus) Hegyi Bence (1987-) (élettanász) Horváth Balázs (1981-) (élettanász) Ruzsnavszky Ferenc (1984-) (élettanász) Váczi Krisztina (1987-) (élettanász) Magyar János (1961-) (élettanász) Bányász Tamás (1960-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:	K10015 OTKA K109736 OTKA K101196 OTKA PD101171 OTKA NK104331 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Élettan Kutatócsoport TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP Molekuláris Orvostudomány Doktori Iskola TÁMOP-4.2.4.A/2-11/1- 2012-0001 TÁMOP
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